非甾体抗炎药物萘丁美酮的合成研究  

Study on the synthesis of nonsteroidal anti-inflammatory drugs nabumetone

作　　者：周石洋[1,2] 杨善彬[1,2] 

机构地区：[1]重庆师范大学化学学院,重庆401331 [2]重庆师范大学活性物质生物技术教育部工程研究中心制剂工程研究所,重庆401331

出　　处：《中国抗生素杂志》2017年第9期780-783,共4页Chinese Journal of Antibiotics

基　　金：重庆市社会民生科技创新专项(No.cstc2015shmszx80060);活性物质生物技术教育部工程研究中心开放基金项目(No.20150408)

摘　　要：目的研究非甾体抗炎药物萘丁美酮的新合成路线。方法以2-甲基-6萘酚为起始原料,经过甲基化、氯化、烷基化和脱羧反应,合成目标产物萘丁美酮。结果在最佳实验条件下目标产物的总收率达86.5%,其中间产物和目标产物的化学结构均经1H NMR、13C NMR和MS等方法进行了表征。结论该合成路线具有操作简单,收率高等优点。Objective To study the new synthetic route of the nonsteroidal anti-inflammatory drugs naphthalene. Methods The synthesis of nabumetone was accomplished using 2-methyl-6-naphthol as the starting material, by a route involving reactions of methylation, chlorination, alkylation and decarboxylation. Results The total yield of the target product was 86.5% under the optimum experimental characterized by 1H NMR, 13C NMR and MS. Conclusion and a high overall yield. conditions. The chemical structure of the final product was The synthetic route has the advantages of simple operations

关 键 词：萘丁美酮 表征 目标产物 

分 类 号：R97[医药卫生—药品]