高原低压低氧环境对心肺结构与功能的影响研究进展  

Effects of hypoxia on cardiopulmonary structure and function at high altitude:a review of recent studies

作　　者：董旭[1,2] 申广浩 谢康宁[1] 景达[1] 刘娟[1] 翟明明[1] 罗二平[1] 

机构地区：[1]第四军医大学生物医学工程学院,陕西西安710032 [2]海军青岛第一疗养院医务部科训科

出　　处：《环境与健康杂志》2017年第6期547-551,共5页Journal of Environment and Health

基　　金：国家科技支撑计划项目(2012BAI20B00);"十二五"全军后勤科研项目(CWS12J098)

摘　　要：该文结合近年来国内外高原医学相关研究进展,对高原低压低氧环境对心肺结构与功能的影响进行综述。主要包括高原低压低氧环境对心肌结构与心脏功能的影响,对肺动脉结构与肺功能的影响,以及相关分子生物学机制的介绍和初步探讨;提出可通过测量、对比平原世居者高原暴露前后的每搏输出量(SV)和静息状态下左室扭转率来综合评价其运动能力,通过区分功能代偿与失代偿来分类研究急慢性低压低氧环境对肺功能的影响更有意义。The effects of hypoxia on cardiopulmonary structure and function were reviewed in this paper in the light of recent studies on high altitude medicine at home and abroad. The effects of hypoxia on myocardial structure and cardiac function,pulmonary artery structure and pulmonary function and the related molecular biology mechanism were discussed. It is suggested that the measurements of stroke volume and left ventricular twist rate in resting state can evaluate the exercise ability of lowland natives under the condition of high altitude hypoxia. It may be more meaningful to study the effects of acute and chronic hypoxia on lung function by distinguishing between functional compensation and decompensation.

关 键 词：高原 缺氧 心肺结构 心肺功能 

分 类 号：R181.3[医药卫生—流行病学]