胃康宁颗粒与胃复春片治疗慢性萎缩性胃炎癌前病变的临床对照研究  

Clinical contrast study of Weikangling and Weifuchun for chronic atrophic gastritis and precancerous lesions

作　　者：侯建明[1] 杨改姣[1] 宋永玲[1] 

机构地区：[1]安阳市第三人民医院消化内科,河南安阳455000

出　　处：《药物评价研究》2017年第8期1138-1140,共3页Drug Evaluation Research

摘　　要：目的探讨胃康宁颗粒与胃复春片治疗慢性萎缩性胃炎(CAG)癌前病变的临床效果。方法将安阳市第三人民医院自2012年1月—2016年12月收治的CAG癌前病变患者85例作为研究对象,随机分为对照组41例和研究组44例,对照组给予胃复春片治疗,研究组给予胃康宁颗粒治疗,比较两组治疗前后的病理积分及临床疗效。结果两组治疗后炎症、萎缩、肠化生积分均明显较治疗前减小,同组治疗前后比较差异有统计学意义(P<0.05);研究组炎症、肠化生积分明显小于对照组,差异有统计学意义(P<0.05)。研究组临床总有效率为90.91%,明显高于对照组的75.61%,差异有统计学意义(P<0.05)。结论胃康宁颗粒治疗CAG癌前病变效果显著,尤其对炎症、肠化生等组织学变化有明显的改善作用,临床应用价值高。Objective To explore the clinical effect of Weikangling and Weifuchun treatment of chronic atrophic gastritis and precancerous lesions. Methods 85 cases of CAG precancerous lesions treated in our hospital from Jan. 2012 to Dec. 2016 were selected as the research object, and were randomly divided into control group （n = 41） and study group （n = 44）. The control group were given Weifuchun, and the study group were given Wei Kangling. The pathological score and clinical efficacy were compared between the two groups before and after treatment. Results After treatment, inflammation, atrophy, intestinal metaplasia scores of the two groups were significantly decreased than before treatment in addition to dysplasia （P 〈 0.05）, and inflammation and intestinal metaplasia in the study group were significantly lower than those in the control group （P 〈 0.05）. The total effective rate of the study group was 90.91%, which was higher than75.61% of the control group （P 〈 0.05）. Conclusions The effect of Wei Kangling in treating precancerous lesions of CAG is significant, especially for the histological changes of inflammation and intestinal metaplasia.

关 键 词：慢性萎缩性胃炎 癌前病变 胃复春片 胃康宁颗粒 

分 类 号：R979.1[医药卫生—药品]