白术升降汤联合琥珀酸普芦卡必利治疗慢性功能性便秘的临床研究  

Clinical Observation of Baizhu Shengjiang Decoction Combined with Prucalopride Succinate Tablets for Treatment of Chronic Functional Constipation

作　　者：黄志芳[1,2] 魏志军[1] 廖颖婴[1] 吴喜华[1] 张婧茹 HUA NG Zhi-Fang WEI Zhi-Jun LIAO Ying-Ying WU Xi-Hua ZHANG Jing-Ru(Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen 518000 Gnangdong, China The Fourth Clinical Medicine School, Guangzhou University of Chinese Medicine, Shenzhen 518000 Guangdong, China)

机构地区：[1]深圳市中医院,广东深圳518000 [2]广州中医药大学第四临床医学院,广东深圳518000

出　　处：《广州中医药大学学报》2017年第5期647-650,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：深圳市科技创新委员会科研课题(编号:JCYJ20160428175517213)

摘　　要：【目的】观察白术升降汤联合琥珀酸普芦卡必利治疗慢性功能性便秘的效果。【方法】将60例慢性功能性便秘患者随机分为治疗组和对照组,每组各30例,治疗组给予白术升降汤联合琥珀酸普芦卡必利治疗,对照组给予单纯口服琥珀酸普芦卡必利治疗,观察2组患者的中医证候疗效、便秘症状改善疗效、随访疗效和疗程结束后3个月的复发情况。【结果】(1)中医证候疗效:治疗组和对照组的治愈率分别为90.0%、60.0%,治疗组的中医证候疗效优于对照组(P<0.05)。(2)便秘症状改善疗效:治疗组和对照组的显效率分别为93.3%、50.0%,总有效率分别为100.0%、73.3%,2组比较,治疗组的便秘症状改善疗效优于对照组(P<0.05或P<0.01)。(3)随访疗效:治疗期内每周完全自发排便≥3次患者的比例,治疗组为86.7%,对照组为53.3%,治疗组的随访疗效优于对照组(P<0.05)。(4)疗程结束后3个月随访,治疗组1例复发,对照组6例复发,治疗组的复发例数明显少于对照组,差异有统计学意义(P<0.05)。【结论】中药白术升降汤结合琥珀酸普芦卡必利治疗慢性功能性便秘,疗效满意,既可以更好地改善患者的便秘情况,又可以降低复发率。Objective To observe the therapeutic effect of Baizhu Shengjiang Decoction combined with Prucalopride Succinate Tablets for chronic functional constipation. Methods Sixty patients with chronic functional constipationwere randomly divided into treatment group and control group,30 cases in each group. The treatment group was treated with Baizhu Shengjiang Decoction combined with Prucalopride Succinate Tablets orally,and the control group was treated with oral administration of Prucalopride Succinate Tablets alone. The therapeutic effects on traditional Chinese medicine（TCM）symptoms and constipation,and the follow-up therapeutic effect of the two groups were evaluated after treatment. During the three months after the completion of treatment course, the recurrence of constipation was monitored. Results（1） The cure rate of the treatment group was 90.0% and that of the control group was 60.0%,indicating that the therapeutic effect on TCM symptoms in the treatment group was stronger than that of the control group（P 〈0.05）.（2） In respect of the relief of constipation,the markedly effective rate was 93.3% in the treatment group and was 50.0% in the control group, and the overall effective rate was 100.0% in the treatment group and was 73.3% in the control group, the difference being significant between the two groups（P 〈0.05 or P 〈0.01）.（3）During the treatment,the percentage of patients with weekly completely spontaneous defecation frequency ≥3 was 86.7% in the treatment group, and was 53.3% in the control group, the difference being significant（P 〈0.05）.（4） The results of 3-month follow-up after the completion of treatment course showed that one case from the treatment group had the recurrence of constipation,and the recurred cases from the control group were 6,the difference being significant（P 〈0.05）. Conclusion Oral use of Baizhu Shengjiang Decoction combined with Prucalopride Succinate Tablets exerts certain therapeutic effect for chronic functional constipation, which

关 键 词：慢性功能性便秘 白术升降汤 琥珀酸普芦卡必利 

分 类 号：R256-35[医药卫生—中医内科学]