培元生金通窍汤治疗儿童哮喘并变应性鼻炎的临床研究  

Clinical Observation of Peiyuan Shengjin Tongqiao Decoction for Treatment of Childhood Asthma Complicated with Allergic Rhinitis

作　　者：曾莺[1] 黎燕珊[1] 陈艳洋[1] ZENG Ying LI Yan-Shan CHEN Yan-Yang(Dept. of Pediatrics, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000 Guangdong, Chin)

机构地区：[1]广东省佛山市中医院儿科,广东佛山528000

出　　处：《广州中医药大学学报》2017年第5期659-663,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省佛山市医学类科技攻关项目(编号:2014AB00335)

摘　　要：【目的】探讨培元生金通窍汤对哮喘合并变应性鼻炎患儿的中医症候评分及肺功能的影响。【方法】将55例支气管哮喘合并变应性鼻炎患儿随机分成治疗组28例和对照组27例。对照组给予布地奈德福莫特罗粉吸入剂吸入治疗,治疗组在此基础上加用培元生金通窍汤治疗。3个月后评价临床疗效,并比较2组患儿中医症候评分和肺功能指标第1秒用力呼气容积占预计值的百分比(FEV1%)及呼气峰流速值占预计值的百分比(PEF%)的变化情况。【结果】(1)经治疗3个月后,治疗组总有效率为92.86%,优于对照组的81.48%,差异有统计学意义(P<0.01)。(2)治疗后,2组患儿咳嗽加喘息评分、鼻炎症候评分及中医症候总评分均较治疗前明显降低(P<0.01),且治疗组治疗后的鼻炎症候评分及中医症候总评分明显低于对照组(P<0.01)。(3)治疗后,2组患儿肺功能PEF%和FEV1%均较治疗前明显改善(P<0.05),且治疗组的改善作用明显优于对照组,差异有统计学意义(P<0.05)。【结论】培元生金通窍汤能改善患儿的鼻炎症候评分、中医症候总评分和肺功能,从而提高哮喘和变应性鼻炎的控制水平。Objective To investigate the effects of Peiyuan Shengjin Tongqiao Decoction, a Chinese herbal recipe with the actions of supplementing kidney to strengthen lung and dredging orifices,on traditional Chinese medicine（TCM） symptoms and lung function of childhood asthma complicated with allergic rhinitis. Methods Fifty-five childhood asthma complicated with allergic rhinitis were randomized into treatment group（N = 28）and control group（N = 27）. The two groups were treated with Budesonide and Formoterol Fumarate Powder for Inhalation, and the treatment group was given oral use of Peiyuan Shengjin Tongqiao Decoction additionally.After treatment, the clinical efficacy of the two groups was evaluated, and TCM symptom scores and lung function indexes [ the percentage of forced expiratory volume in the first second to the expected value（FEV1%）and the percentage of peak expiratory flow to the expected value（PEF%）] were also observed before and after treatment. Results（1）After treatment for 3 months,the total effective rate of the treatment group was 92.86%,being superior to that of the control group（81.48%）,and the difference was significant（P〈 0.01）.（2）After treatment,the scores of cough plus asthma,rhinitis symptom scores and overall TCM symptom scores of the two groups were decreased（P〈 0.01 compared with those before treatment）,and the rhinitis symptom scores and overall TCM symptom scores of the treatment group were lower than those of the control group（P〈 0.01）.（3）After treatment,PEF% and FEV1% were both improved in the two groups（P〈 0.05 compared with those before treatment）,and the improvement in the treatment group was superior to that in the control group（P 〈0.05）. Conclusion Peiyuan Shengjin Tongqiao Decoction is effective for the control of childhood asthma complicated with allergic rhinitis by improving rhinitis symptom scores, overall TCM symptom scores and lung function.

关 键 词：培元生金通窍汤 儿童哮喘 变应性鼻炎 肺功能 中医症候评分 

分 类 号：R259.622[医药卫生—中西医结合]