2型糖尿病患者骨碱性磷酸酶25羟维生素D及骨钙素水平  

Analysis of BAP,25 Hydroxy Vitamin D and Osteocalcin Level in Patients with Type 2 Diabetes Mellitus

作　　者：金鑫[1] 吴飞妮 陈海波[1] 任雪丽[1] 刘杰[1] 叶靖[1] 邓丽丽[1] 

机构地区：[1]陕西省安康市人民医院内分泌科,陕西安康725000

出　　处：《贵州医科大学学报》2017年第9期1111-1113,1116,共4页Journal of Guizhou Medical University

基　　金：陕西省安康市科技厅资助项目(编号:2011JQ4014G)

摘　　要：目的:探讨2型糖尿病患者骨碱性磷酸酶(BAP)、25羟维生素D及骨钙素水平。方法:48例2型糖尿病患者为观察组,同期48例健康体检者为对照组,两组女性均为绝经期妇女;观察组患者于入院时、对照组被检者于体检时抽取静脉血,采用全自动化生化分析仪测定血清中骨碱性磷酸酶(BAP)、25羟维生素D[25(OH)D3]及空腹血糖(FPG)、血清肌酐(SCr)、糖化血红蛋白(Hb Alc)水平,采用采用全自动电化学发光免疫分析仪测定血清骨钙素(OC)水平。结果:与对照组比较,观察组FPG、血SCr、Hb Alc水平浓度升高(P<0.05);与对照组男性比较,观察组男性25(OH)D3、OC水平降低,而BAP水平升高(P<0.05);与对照组女性比较,观察组女性25(OH)D3、OC水平降低,而BAP水平升高(P<0.05)。结论:2型糖尿病患者BAP水平升高,而25(OH)D3及OC水平降低。Objective： To investigate BAP, 25 Hydroxy Vitamin D and osteocalcin level in patients with type 2 diabetes mellitus. Methods： 48 type 2 diabetes patients as observation group, and 48 vol- unteers as control group. All females were menopausal women. Both groups after admission were car- ried on the extraction of venous blood, and then biochemistry analyzer was adopted to determine BAP, 25 Hydroxy Vitamin D [ 25 （OH）D3 ] and osteocalcin level, FPG, SCr and HbAlc levels; EIECSYS was adopted to determine OC. Results： Compared with control group, FPG, Serum SCr, HbAlc levels in observation group increased （ P 〈 0. 05 ） ; compared with males of control group, 25 （OH） D3 and OC level of males of observation group decreased, while BAP level increased （ P 〈 0. 05 ）, compared with females of control group, 25 （OH） D3 and OC level of females of observation group decreased, while BAP level increased （P 〈 0. 05 ）. Conclusion： Concerning type 2 diabetes mellitus patients, BAP lev- el increased, while 25 （OH）D3 and OC level decreased.

关 键 词：糖尿病 碱性磷酸酶 25羟维生素D 骨钙素 血糖 肌酐 血红蛋白A 糖基化 

分 类 号：R587[医药卫生—内分泌] R580[医药卫生—内科学]