霍乱弧菌生物被膜发育与环境调控  

Biofilm development and environmental determinants in Vibrio cholerae

作　　者：王全民 马遥 刘丽钧 朱军 刘智[1] 

机构地区：[1]华中科技大学生命科学与技术学院,湖北武汉430074

出　　处：《生物工程学报》2017年第9期1533-1546,共14页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(No.81572050)资助~~

摘　　要：生物被膜状态的霍乱弧菌具有极强的环境适应性和超高的感染性,生物被膜的发育调控研究对霍乱弧菌的宿主感染和环境适应非常重要。本文综述了近年来霍乱弧菌生物被膜研究结果,包括霍乱弧菌生物被膜的组成、发育和环境调控,尤其着重阐述了各种环境因子对霍乱弧菌生物被膜发育的影响,包括细菌自体信号分子、自然环境因子和宿主信号分子。Biofilm associated Vibrio cholerae exhibits hypervirulence and supreme fitness against the harsh stresses during its infectious cycle. It is important to study the relationships between the regulation mechanism of V. cholerae biofilm development and its environmental adaption in host niche and aquatic habitat. Here, we summarize the recent advances in V. cholerae biofilm, including biofilm compositions, development and regulation. Particularly, we extensively discuss how Is. cholerae fosters its biofilm architecture and assembly via sensing and responding various environmental determinants, such as bacterium self-produced molecules, natural environment components and host factors.

关 键 词：生物被膜 霍乱弧菌 环境因子 

分 类 号：R378.3[医药卫生—病原生物学]