加味补阳还五汤辅助预防气虚血淤型脑血管支架内再狭窄的临床效果观察  

Clinical efficacy of modified Buyang Huanwu Decoction for supplementary prevention of cerebrovascular in-stent restenosis of Qi deficiency and blood stasis type

作　　者：周欣梅[1] 陈晓锋[1] 曾振[1] ZHOU Xin-mei CHEN Xiao-feng ZENG Zhen(Department of Neurology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011, China)

机构地区：[1]广西中医药大学附属瑞康医院神经内科,南宁市530011

出　　处：《广西医学》2017年第9期1355-1357,共3页Guangxi Medical Journal

摘　　要：目的观察加味补阳还五汤辅助预防气虚血淤型脑血管支架内再狭窄(ISR)的临床疗效。方法将86例拟行血管支架置入术颅内外血管狭窄患者随机分为对照组42例和观察组44例。两组术前均给予氯比格雷及阿司匹林抗凝,观察组在此基础上加用加味补阳还五汤,疗程均为6个月。比较两组治疗前后血管狭窄程度、ISR发生率及中医临床疗效。结果治疗前,两组中医证候积分比较差异无统计学意义(P>0.05),治疗后,两组中医证候积分均较治疗前下降,且观察组低于对照组(均P<0.05)。治疗后,两组血管狭窄程度与血管参考直径比较,差异均无统计学意义(P>0.05),但观察组支架段直径大于对照组,直径减少指数及ISR发生率低于对照组,中医临床疗效优于对照组(均P<0.05)。结论加味补阳还五汤辅助防治气虚血淤型脑血管ISR效果较好。Objective To observe the clinical efficacy of modified Buyang Huanwu Decoction for supplementary prevention of cerebrovascular in-stent restenosis（ISR） of Qi deficiency and blood stasis type.Methods A total of 86 patients with intracranial/extracranial arterial stenosis scheduled to undergo cerebral artery stenting were randomly divided into control group （n=42） and observation group（n=44）.The two groups were given anticoagulation therapy with clopidogrel and aspirin before operation ,while the observation group was administered modified Buyang Huanwu Decoction additionally on the basis of anticoagulation therapy .The treatment lasted for six months.The degree of angiostenosis,incidence rate of ISR,and clinical efficacy of traditional Chinese medicine were compared between the two groups before and after treatment.Results Before treatment,there were no significant differences in the syndrome score of traditional Chinese medicine between the two groups （P〉0.05）,after treatment,the syndrome score of traditional Chinese medicine decreased in both groups,and the score of the observation group was lower than that of the control group（all P〈0.05）.After treatment,there were no significant differences in the degree of angiostenosis or reference vessel diameter between the two groups（P〉0.05）,and the stent diameter was greater,diameter reduction index and incidence rate of ISR were lower ,and clinical efficacy of traditional Chinese medicine was better in the observation group compared to the control group（all P〈0.05）.Conclusion Modified Buyang Huanwu Decoction has a good efficacy for supplementary prevention of cerebrovascular ISR of Qi deficiency and blood stasis type .

关 键 词：支架内再狭窄 脑血管 补阳还五汤 加味 气虚血淤 颅内外血管狭窄 

分 类 号：R289.5[医药卫生—方剂学] R743.91[医药卫生—中药学]