他达那非两种给药方法治疗慢性前列腺炎合并勃起功能障碍的临床疗效比较  

Effects of tadalafil in the treatment of chronic prostatitis combined with erectile dysfunction: on-demand versus long-term low-dosing

作　　者：陈春胜 史南 黄永湘 类成勇[3] 

机构地区：[1]儋州市人民医院泌尿外科,海南儋州571700 [2]儋州市人民医院骨科,海南儋州571700 [3]南方医科大学南方医院泌尿科,广州510515

出　　处：《中国性科学》2017年第9期29-31,共3页Chinese Journal of Human Sexuality

摘　　要：目的:比较按需给药和长期小剂量口服他达那非两种给药方法治疗慢性前列腺炎合并勃起功能障碍的临床疗效。方法:将80例慢性前列腺炎合并勃起功能障碍的患者随机分为A组(按需给药组)和B组(5mg他达那非组),每组40例。比较两组患者治疗前后NIH-CPSI、IIEF-5、SD和SAS评分的变化情况,记录治疗总有效率,并评估他达那非的安全性及耐受性。结果:两组治疗后NIH-CPSI和IIEF-5评分较治疗前明显改善(P<0.05);B组患者治疗后IIEF-5评分改善情况优于A组(P<0.05);两组治疗后SDS和SAS评分较治疗前明显降低(P<0.05);B组患者治疗后SDS和SAS评分低于A组(P<0.05);B组治疗总有效率显著高于A组,差异有统计学意义(P<0.05);本研究未出现严重不良反应。结论:长期小剂量(5mg/d)口服他达那非治疗慢性前列腺炎合并勃起功能障碍可以提高患者性自信,改善勃起功能障碍,治疗有效率高且耐受性强。Objectives： To investigate effects of tadalafil in the treatment of chronic prostatitis combined with erectile dysfunction ： on - demand versus long - term low - dosing. Methods ： 80 patients with chronic prostati- tis with erectile dysfunction were randomly divided into group A （ on - demand dosing group） and group B （ 5 mg tadalafil group）, with 40 cases in each group. The changes in NIH -CPSI, IIEF -5, SDS and SAS scores of two groups were compared before and after treatment. The total efficiency of treatment was recorded so as to assess the safety and tolerability of tadalafil. Results： NIH - CPSI and IIEF - 5 scores of the two groups were significantly im- proved （ P 〈 0. 05 ）. After treatment, the IIEF - 5 of group B was better than that of group A （ P 〈 0. 05 ） ; the SDS and SAS of two groups were lower than these before treatment （P 〈 0. 05） ; the SDS and SAS of group B were lower than those of group A （P 〈 0. 05）. The total effective rate of group B was significantly higher than that of group A, with statistically significant difference （P 〈 0. 05 ）. Conclusion： Long - term low - dosing oral tadalafil （5mg/d） for the treatment of chronic prostatitis with erectile dysfunction can improve the confidence of patient and the treat- ment effect of erectile dysfunction, with high efficiency and strong tolerance.

关 键 词：慢性前列腺炎 勃起功能障碍 他达那非 临床疗效 

分 类 号：R698[医药卫生—泌尿科学]