贝那普利联合美托洛尔治疗老年原发性高血压伴心力衰竭的疗效分析  

Analysis of Therapeutic Efficacy of Benazepril Combined with Metoprolol in the Treatment of Elderly Essential Hypertension Complicated with Heart Failure

作　　者：潘花[1] 印建荣[2] 

机构地区：[1]邳州市人民医院药剂科,江苏邳州221300 [2]邳州市人民医院心内科,江苏邳州221300

出　　处：《中国药房》2017年第27期3788-3790,共3页China Pharmacy

摘　　要：目的:观察贝那普利联合美托洛尔治疗老年原发性高血压伴心力衰竭的疗效和安全性。方法:回顾性分析100例老年原发性高血压伴心力衰竭患者资料,按用药方案的不同分为对照组(50例)和观察组(50例)。在常规治疗的基础上,对照组患者给予盐酸贝那普利片10 mg,口服,每日1次;观察组患者在对照组治疗的基础上给予酒石酸美托洛尔片初始剂量6.25 mg,口服,每日2次,后视患者病情,增加至50~100 mg,口服,每日2次。治疗6个月后观察两组患者的临床疗效,治疗前后收缩压(SBP)、舒张压(DBP)、肱-踝脉搏波传导速度(ba PWV)、静息心率、左室射血分数(LVEF)、每搏输出量(SV)及不良反应发生情况。结果:观察组患者总有效率(88.0%)显著高于对照组(62.0%),差异有统计学意义(P<0.05)。治疗前,两组患者SBP、DBP、ba PWV、静息心率、LVEF、SV比较,差异均无统计学意义(P>0.05)。治疗后,两组患者SBP、DBP、ba PWV均显著低于同组治疗前,且观察组显著低于对照组;两组患者LVEF、SV均显著高于同组治疗前,且观察组显著高于对照组;观察组患者静息心率显著低于同组治疗前及对照组,差异均有统计学意义(P<0.05);但对照组治疗前后静息心率比较,差异无统计学意义(P>0.05)。两组患者治疗期间均未见明显不良反应发生。结论:在常规治疗的基础上,贝那普利联合美托洛尔治疗老年原发性高血压伴心力衰竭的疗效显著,可改善患者心功能及血压,且安全性较好。OBJECTIVE： To observe therapeutic efficacy and safety of benazepril combined with metoprolol in the treatment of elderly essential hypertension complicated with heart failure. METHODS： In retrospective analysis, 100 elderly patients with essen- tial hypertension complicated with heart failure were divided into control group （50 cases） and observation group （50 cases） accord- ing to drug plan. Based on routine treatment, control group was given Benazepril hydrochloride tablet 10 mg orally, once a day. Observation group was additionally given Metoprolol tartrate tablet with initial dose of 6.25 mg, twice a day, then increased 50-100 mg based on the improvement, twice a day, on the basis of control group. Relevant indicators were observed after 6 months of treat- ment. Clinical efficacies as well as SBP, DBP, brachial-ankle pulse wave velocity （baPWV）, resting heart rate, LVEF, SV and the occurrence of ADR before and after treatment were observed in 2 groups. RESULTS： Total response rate of observation group （88.0%） was significantly higher than that of control group （62.0%）, with statistical significance （P〈0.05）. Before treatment, there was no statistical significance in SBP, DBP, baPWV, resting heart rate, LVEF and SV between 2 groups （P〉0.05）. After treatment, SBP, DBP and baPWV of 2 groups were significantly lower than before, and the observation group was significantly lower than the control group; LVEF and SV of 2 groups were significantly higher than before, and the observation group was sig- nificantly higher than the control group; resting heart rate of observation group was significantly lower than before and that of con- trol group, with statistical significance （P〈0.05）, but there was no statistical significance in resting heart rate of control group be- fore and after treatment （P〉0.05）. No significant ADR was found in 2 groups during treatment. CONCLUSIONS： Based on rou- tine treatment, benazepril combined with metoprolol show significant therapeutic

关 键 词：老年 原发性高血压 心力衰竭 贝那普利 美托洛尔 疗效 安全性 

分 类 号：R544[医药卫生—心血管疾病]