海昆肾喜胶囊治疗慢性肾功能衰竭的Meta分析  

Meta-analysis of Haikun Shenxi Capsule in the Treatment of Chronic Renal Failure

作　　者：刘枚芳 黄家晟 何嘉炜 华俏丽 张蕾[1,3] 刘旭生 

机构地区：[1]广东省中医院,广州510120 [2]广州中医药大学第二临床医学院,广州510405 [3]广州中医药大学第二附属医院,广州510120

出　　处：《中国药房》2017年第27期3801-3804,共4页China Pharmacy

基　　金：国家科技支撑计划课题(No.2013BAI02B04);广东省中医院中医药科学技术研究专项项目(No.2014KT1305)

摘　　要：目的:系统评价海昆肾喜胶囊治疗慢性肾功能衰竭(CRF)的疗效,为临床提供循证参考。方法:计算机检索Central、Pub Med、EMBase、中国期刊全文数据库(CJFD)、中国生物医学文献数据库(CBM)、中文科技期刊数据库(VIP)和万方数据库,收集海昆肾喜胶囊联合常规方案(试验组)对比单纯常规方案(对照组)治疗CRF的随机对照试验(RCT),筛选文献、提取资料并采用Cochrane协作网提供的风险偏倚评估图评价质量后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入10项RCT,合计704例患者。Meta分析结果显示,试验组患者总有效率显著高于对照组[RR=4.42,95%CI(2.70,7.22),P<0.001],血肌酐[MD=-140.37,95%CI(-191.72,-89.03),P<0.001]、血尿素氮[MD=-5.49,95%CI(-8.36,-2.63),P<0.001]和24 h尿蛋白定量[MD=-0.43,95%CI(-0.62,-0.23),P<0.001]均显著低于对照组,差异均有统计学意义。结论:海昆肾喜胶囊治疗CRF疗效较好,可以显著改善患者相关肾功能指标。OBJECTIVE： To systematically review therapeutic efficacy of Haikun shenxi capsule in the treatment of chronic re- nal failure （CRF）. METHODS： Retrieved from Central, PubMed, EMBase, CJFD, CBM, VIP and Wanfang database, random- ized clinical trials （RCTs） about Haikun shenxi capsule combined with routine treatment （trial group）vs, single routine treatment （control group） in the treatment of CRF were collected. Meta-analysis was performed by Rev Man 5.3 software after screening liter- attire, extracting data and evaluating quality by using risk bias evaluation of Cochrane collaboration network. RESULTS ： A total of 10 RCTs were included eventually, involving 704 patients. The results of analysis showed that compared to general therapy, Hai- kun shenxi capsule could improve total effective rate [RR = 4.42,95 % CI （ 2.70,7.22 ）, P〈 0.001], and could reduce SCr[MD = - 140.37,95 % CI （ - 191.72, - 89.03 ）, P〈 0.001], BUN[MD = - 5.49,95 % CI （ - 8.36, - 2.63）, P〈 0.001] and 24 h-Upro [MD = - 0.43,95 % CI （ - 0.62, - 0.23）, P〈0.001], with statistical significance. CONCLUSIONS： The clinical efficacy of Haikun shenxi capsule in the treatment of CRF is good and significantly improve related indexes of renal function.

关 键 词：海昆肾喜胶囊 慢性肾功能衰竭 META分析 系统评价 疗效 

分 类 号：R692.5[医药卫生—泌尿科学]