血府逐瘀汤辅助治疗不稳定型心绞痛的Meta分析  

Meta-analysis of Xuefu Zhuyu Decoction in the Adjuvant Treatment of Unstable Angina Pectoris

作　　者：郭惟[1] 庄振杰[2] 鲁可[2] 温俊茂 吴伟[3] 

机构地区：[1]广州中医药大学第四临床医学院2013级,广东深圳518000 [2]广州中医药大学第一临床医学院,广州510405 [3]广州中医药大学第一附属医院,广州510405

出　　处：《中国药房》2017年第27期3809-3812,共4页China Pharmacy

基　　金：国家中医药管理局资助项目(No.JDZX2015241);广东省中医药管理局资助项目(No.2015LP01)

摘　　要：目的:系统评价血府逐瘀汤辅助治疗不稳定型心绞痛的疗效,为临床提供循证参考。方法:计算机检索Pub Med、EMBase、Cochrane图书馆、中国期刊全文数据库(CJFD)、万方数据库、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM),收集血府逐瘀汤联合常规方案(试验组)对比单纯常规方案(对照组)治疗不稳定型心绞痛的随机对照试验(RCT),提取RCT资料并按照Cochrane系统评价员手册5.1.0评价质量后,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入12项RCT,合计1 252例患者。Meta分析结果表明,试验组患者总有效率[OR=3.56,95%CI(2.49,5.10),P<0.001]、血清高密度脂蛋白水平[WMD=0.25,95%CI(0.05,0.45),P=0.01]和心电图改善率[OR=2.76,95%CI(1.97,3.87),P<0.001]均显著高于对照组,血清总胆固醇[WMD=-1.14,95%CI(-1.46,-0.82),P<0.001]、三酰甘油[WMD=-0.53,95%CI(-0.84,-0.22),P<0.001]和C反应蛋白水平[WMD=-0.91,95%CI(-1.14,-0.69),P<0.001]均显著低于对照组,差异均有统计学意义。结论:血府逐瘀汤辅助治疗不稳定型心绞痛疗效较好,可显著改善患者血脂和炎症因子水平。OBJECTIVE： To systematically evaluate therapeutic efficacy of Xuefu zhuyu decoction in the adjuvant treatment of unstable angina pectoris （UAP） , and to provide systematic evidence-based reference in clinic. METHODS： Retrieved from PubMed, EMBase, Cochrane library, CJFD, Wanfang database, VIP and CBM, randomized controlled trials （RCTs） about Xuefu zhuyu decoction＋conventional treatment （trial group） vs. single conventional treatment （control group） in the treatment of UAP were collected. Meta-analysis was performed by using Rev Man 5.2 statistical software after data extraction and Cochrane systemat- ic review manual 5.1.0. RESULTS： Totally 12 RCTs were included, involving 1 252 patients. The results of Meta-analysis showed that total response rate [OR=3.56,95%CI（2.49,5.10） ,P〈0.001], serum HDL[WMD=0.25,95%CI（0.05,0.45） ,P=0.01] and the rate of ECG improvement [OR = 2.76, 95 % CI （ 1.97, 3.87）, P 〈 0.001] of trial group were significantly higher than those of control group, while serum TC [WMD= - 1.14,95%CI（ - 1.46, -0.82） ,P〈0.001], TG [WMD= -0.53,95%CI（ -0.84, -0.22） ,P〈 0.001] and CRP [WMD=- 0.91, 95% CI（- 1.14,- 0.69）, P〈0.001] levels of trial group were significantly lower than those of control group, with statistical significance. CONCLUSIONS： Therapeutic efficacy of Xuefu zhuyu decoction in adjuvant treatment have zood theraoeutic efficacy and can siznificantlv imorove the blood lioid and inflammatory factors level.

关 键 词：血府逐瘀汤 不稳定型心绞痛 系统评价 疗效 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]