达沙替尼致可逆性毛发色素脱失  

Reversible hair depigmentation induced by dasatinib

作　　者：魏爱玲[1] 吴涛[1] 亢婷[1] 刘岩[1] 白海[1] 王存邦[1] 

机构地区：[1]兰州军区兰州总医院全军血液科,730050

出　　处：《药物不良反应杂志》2017年第4期315-317,共3页Adverse Drug Reactions Journal

基　　金：甘肃省自然科学基金（145RJZA151）

摘　　要：1例15岁慢性粒细胞白血病男性患儿因急变为急性淋巴细胞白血病合并中枢神经系统白血病给予达沙替尼50 mg口服,2次/d.用药1年后患儿出现部分头发、眉毛颜色变白;15个月后因腹泻停用达沙替尼,改为口服甲磺酸伊马替尼400 mg/d.停用达沙替尼2个月后患儿毛发明显转黑.1周后因疾病进展再次给予达沙替尼（50 mg,2次/d）,6个月后部分头发、眉毛变白再次出现.A 15-year-old boy with chronic myelogenous leukemia, since acute conversion to lymphoblastic leukemia and central nervous system leukemia received oral dasatinib 50 mg twice daily.One year later, the boy′s color of partial hair and eyebrow became white.Three months later, dasatinib was replaced by imatinib mesylate due to diarrhea.Two months after dasatinib withdrawal, his hair returned to black.One week later, dasatinib 50 mg twice daily was given again due to leukemia relapse.Six months later, the color of part of his hair and eyebrow became white again.

关 键 词：达沙替尼 毛发颜色 

分 类 号：R979.1[医药卫生—药品]