右美托咪定对小儿七氟烷麻醉后苏醒期躁动的影响  

Influences of dexmedetomidine on agitation during recovery after applying sevoflurane anesthesia to pediatric patients

作　　者：宋斌[1] 吴秀玲[1] 陈月芝[1] 雷波 Song Bin Wu Xiuling Chen Yuezhi Lei Bo(Department of Anesthesiology, Xinjiang Shihezi City People＇s Hospital, Shihezi 832000, China Department of Anesthesiology, Xinjiang Uygur Autonomous Region Chinese Medicine Hospital, Urumqi 830000, China)

机构地区：[1]新疆石河子市人民医院,新疆石河子832000 [2]新疆自治区中医医院麻醉科,新疆乌鲁木齐830000

出　　处：《江苏科技信息》2017年第27期35-39,共5页Jiangsu Science and Technology Information

摘　　要：目的:探讨右美托咪定对小儿七氟烷麻醉后苏醒期躁动的影响。方法:选择2~9岁择期行气管内插管全麻的患儿90例,随机分为对照组、右美托咪定0.15μg/kg组(观察1组)、右美托咪定0.30μg/kg组(观察2组),每组30例。对照组患儿术中吸入七氟烷和空氧混合气体。观察1组和观察2组在此基础上复合静脉连续输注右美托咪定负荷剂量0.15μg/kg,0.30μg/kg。观察各组患儿麻醉前(T_0)、插管前(T_1)、插管后5 min(T_2)和送出PACU时(T3)的收缩压(SBP)、舒张压(DBP)、心率(HR)和血氧饱和度(SPO_2)。记录3组患者手术时间、苏醒时间、PACU停留时间。比较3组患儿的躁动发生率。结果:3组间T_0时间点SPO_2,HR,SBP,DBP差异无统计学意义,3组T_1~T_3期间HR,SBP,DBP差异有统计学意义(P<0.05)。3组患儿在诱导期间各时间点血流动力学变化趋势基本一致。组间比较T_1~T_3时间点观察2组HR,SBP,DBP低于观察1组和对照组,观察1组上述指标低于对照组,差异均有统计学意义(P<0.05),3组各时间点SPO_2值PACU停留时间差异无统计学意义(P>0.05)。3组在不同时间点躁动发生率差异有统计学意义(P<0.05);观察1组和观察2组躁动发生率均明显低于对照组(χ~2分别为:29.39,637.630,P<0.05),但观察1组和观察2组两组比较差异无统计学意义(P>0.05)。3组苏醒时间差异有统计学意义(F=105.610,P=0.000),观察1组、2组苏醒时间明显低于观察组,差异有统计学意义(P<0.05)。结论:静脉连续输注右美托咪定不会显著延长小儿的苏醒时间,且苏醒过程中躁动的发生率明显降低,右美托咪定能预防小儿七氟烷麻醉后苏醒期的躁动反应。Objective： To explore the effects of Dexmedetomidine on restlessness during recovery after conducting Sevoflurane anesthesia on pediatric patients.Methods： 90 cases of children aged 2 to 9 in Shihezi People＇s Hospital were randomly divided into control group,dexmedetomidine 0.15 μg/kg group（observation group 1） and dexmedetomidine0.30 μg/kg group（observation group 2）,altogether 30 cases in each group.The control group was given sevoflurane and air-oxygen.Observation group 1 and group 2 were given dexmedetomidine with the dose of 0.15 μg/kg,0.30 μg/kg respectively.Systolic blood pressure （SBP）,diastolic blood pressure（DBP）,heart rate （HR） and oxygen saturation （SPO_2）were measured in observation group1 and observation group 2 at the time of preauethesia （T_0）,before intubation （T_1）,5minutes after intubation （T_2） and at the time when the PACU （T_3） was sent out.Surgery time,recovery time and PACU stay time was recorded in three groups to compare the agitation incidence of three groups.The results show that the difference among SPO_2,HR,SBP and DBP is not statistically significant while it proves otherwise from T1 to T_3（P 0.05）.During time of T_1-T_3,HR,SBP,DBP of observation group 2 was lower than that of observation group 1,HR,SBP,DBP of observation group 1 was lower than control group（P0.05）.SPO_2 value and time of PACU staying among three groups had no significant difference（P0.05）; agitation incidence of observation group 2 and observation group 1 were lower than control group （χ~2=29.39,637.630,P0.05）.Recovery time in 3 groups had significant differences （F=105.610,P=0.000）.agitation incidence of observation group 2 and observation group 1 were lower than that of control group （P0.05）.This article draws the conclusion that cexmedetomidine can prevent the agitation reaction of children after sevoflurane anesthesia is applied as the intravenous infusion of dexmedetomidine won＇t significantly prolong the child＇s waking time and the

关 键 词：右美托咪定 七氟烷 麻醉 苏醒期躁动 

分 类 号：S859.791[农业科学—临床兽医学]