白癜风免疫发病机制的研究进展  

Research Progress of Immunopathology in Vitiligo

作　　者：王春又 游弋[1] 葛兰[1] 宋志强[1] 郝飞[1] WANG Chunyou YOU Yi GE Lan SONG Zhiqiang HAO Fei.(Department of Dermatology, Southwest Hospital, the Third Military Medical University, Chongqing 400038, Chin)

机构地区：[1]第三军医大学西南医院皮肤科,重庆400038

出　　处：《医学综述》2017年第18期3638-3641,3646,共5页Medical Recapitulate

摘　　要：白癜风为临床常见的色素脱失性疾病,由于皮肤、毛发中功能性黑素细胞减少而发病,临床表现为边界清楚的乳白色斑片,主要分为节段性和非节段性。目前白癜风的病因及发病机制尚未完全明确,可能与遗传、氧化应激、免疫异常等有关。细胞及体液免疫参与白癜风的发病及病情进展,T淋巴细胞、单核-巨噬细胞、促炎因子及自身抗体等均在白癜风的发病中有一定作用。明确机体免疫、自身抗体、细胞因子等对黑素细胞的影响及在白癜风发病中的具体作用是今后研究的方向,也是白癜风治疗的方向。Vitiligo is a common depigmentation skin disease resulting from loss of functional melanocytes from skin and hair. Its clinical manifestation is characterized by the presence of circumscribed white macules in the skin and can be divided into two commonest forms ： segmental and non-segmental vitiligo. The etiology of vitiligo is not thoroughly clear up to now. However, recent researches suggest that genetic, oxidative stress and immunopathologic factors are significant in vitiligo. Cellular and humoral immunity play an important role in the pathology of vitiligo such as T cells, mononuclear mac- rophage, proinflammatory factors and autobodies and so on. It is the direction of the future research and the direction of the treatment of vitiligo to make clear the influence of the body immunity, autoantibody and cytokine on the melanocytes and their specific roles in the pathogenesis of vitiligo.

关 键 词：白癜风 固有免疫 适应性免疫 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]