中药治疗心脑血管疾病、肝肾损伤及抗炎抗病毒的血清代谢组学研究进展  

Research progress of serum metabolomics in the treatment of cardiovascular and cerebrovascular diseases,liver and kidney damage and the anti-inflammatory and anti-viral effects with traditional Chinese medicine

作　　者：王明[1] 刘丹 陈淋 陈丹倩 陈华[1] 赵英永[1] 

机构地区：[1]西北大学西部资源生物与现代生物技术教育部重点实验室,西安710069

出　　处：《药物分析杂志》2017年第9期1549-1556,共8页Chinese Journal of Pharmaceutical Analysis

基　　金：国家自然科学基金(No.81673578;81603271);教育部"新世纪优秀人才计划"项目(No.NCET-13-0954)

摘　　要：代谢组学研究整体代谢轮廓的特点与中医药的整体观念相吻合,代谢组学技术已广泛应用于中药治疗心脑血管疾病、肝肾损伤及抗炎抗病毒的活性评价和生物化学作用机制的研究。本文对基于血清代谢组学的中药治疗心脑血管疾病、肝肾损伤及其抗炎抗病毒的研究进展进行综述。氨基酸、脂肪酸、磷脂、糖类等代谢产物是上述疾病的主要生物标示物,氨基酸代谢、脂肪酸代谢、磷脂代谢、三羧酸循环、能量代谢等是参与这些疾病的主要生物代谢途径。中药对这些异常的代谢有一定的改善作用。代谢组学的研究鉴定了中药治疗这些疾病的生物标示物,并阐明了其生物化学作用机制。The holistic investigation of metabolomics is in agreement with the whole concept thinking of traditional Chinese medicine （ TCM ）. Metabonomic technology has been widely applied to the study of the bioactivities and biochemical action mechanisms of traditional Chinese medicine in the treatment of cardiovascular and cerebrovascular diseases, liver and kidney damage and anti-inflammatory and anti-viral effects. This paper mainly summarizes the application of the serum metabolomics in the treatment of cardio-cerebrovascular disease and liver and kidney injury as well as anti-inflammatory and anti-viral effects of traditional Chinese medicine. The results show that amino acid, fatty acids, phospholipids and carbohydrates are the main biomarkers of above- mentioned diseases. Additionally, these studies successfully demonstrated that amino acid metabolism, fatty acid metabolism, phospholipid metabolism, Principal component analysis （ TCA ） cycle and energy metabolism are the major metabolic pathways of above-mentioned diseases, and traditional Chinese medicine improved these abnormal endogens metabolites and metabolic pathways of above-mentioned diseases to the normal state. Overall, metabolomic research is helpful to find biomarker and elucidate the potential mechanism of traditional Chinese medicine in the treatment with these diseases.

关 键 词：代谢组学 血清 中药 生物标示物 生物化学机制 

分 类 号：R97[医药卫生—药品]