醒脑静联合乙酰谷酰胺治疗急性重度一氧化碳中毒45例临床观察  

Clinical Observation of Xingnaojing Combined with Acetylglutamide for Treating Acute Severe Carbon Monoxide Poisoning in 45 Cases

作　　者：陆岩[1] 方建飞[1] 王芳[1] 罗晓燕[1] 李伟[1] Lu Yah Fang Jianfei Wang Fang Luo Xiaoyan Li Wei(Kailuan General Hospital, Tangshan, Hebei, China 06300)

机构地区：[1]河北省开滦总医院,河北唐山063000

出　　处：《中国药业》2017年第18期70-72,共3页China Pharmaceuticals

摘　　要：目的探讨醒脑静联合乙酰谷酰胺治疗急性重度一氧化碳中毒的临床疗效。方法选择医院2012年1月至2017年1月收治的急性重度一氧化碳中毒患者90例,按随机数字表法分为对照组和观察组,各45例。两组患者均给予高压氧舱、营养神经、甘露醇脱水降颅压和改善循环等基础治疗,对照组患者在此基础上给予乙酰谷酰胺静脉滴注,观察组在对照组治疗基础上给予醒脑静静脉滴注。结果观察组总有效率为93.33%,显著高于对照组的75.56%(P<0.05);治疗后,两组患者格拉斯哥昏迷评分(GCS)和血清超氧化物歧化酶(SOD)水平均明显升高,且观察组升高更显著(P<0.05);观察组患者迟发性脑病发生率为4.44%,显著低于对照组的22.22%(P<0.05)。结论醒脑静联合乙酰谷酰胺治疗急性重度一氧化碳中毒疗效显著,能有效改善患者的临床表现,促进患者意识恢复,升高血清SOD水平,减少迟发性脑病的发生,值得临床推广。Objective To investigate the clinical effect of Xingnaojing combined with acetylglutamide in the treatment of acute severe carbon monoxide poisoning. Methods A total of 90 patients with acute severe carbon monoxide poisoning admitted to our hospital from January 2012 to January 2017 were selected and divided into the control group（ n = 45） and the observation group（ n = 45） according to random number table method. The two groups were treated with hyperbaric oxygen,nutrition nerve,mannitol dehydration to reduce intracranial pressure and improve circulation and other basic treatment,on this basis,the control group was treated with acetylglutamide,while the observation group was additionally treated with Xingnaojing on the basis of the control group. Results The total effective rate of the observation group was 93. 33%,which was significantly higher than 75. 56% of the control group（ P 〈 0. 05）. After treatment,the GCS score and serum SOD level were significantly increased in the two groups,and the observation group was increased more significantly（ P 〈 0. 05）. The incidence rate of delayed encephalopathy of the observation group was 4. 44%,which was significantly lower than 22. 22 % of the control group（ P 〈 0. 05）. Conclusion Xingnaojing combined with acetylglutamide is effective in the treatment of patients with severe acute carbon monoxide poisoning,and it also can reduce the incidence of delayed encephalopathy,which is worthy of clinical promotion.

关 键 词：醒脑静 乙酰谷酰胺 急性重度一氧化碳中毒 临床疗效 

分 类 号：R2-031[医药卫生—中西医结合] R595.1[医药卫生—中医学]