维生素D对骨骼肌健康的影响及其机制的研究进展  

Research Advancement of Vitamin D Effect on Skeletal Muscle and Its Mechanism

作　　者：张琳[1,2] 蔡浩刚[2] 曹振波[1] 

机构地区：[1]上海体育学院运动科学学院,上海200438 [2]商丘师范学院体育学院,河南商丘476000

出　　处：《中国体育科技》2017年第5期133-144,F0003,共13页China Sport Science and Technology

基　　金：国家自然科学基金资助项目(31571226);上海高校特聘教授东方学者项目(TP2014057)

摘　　要：维生素D是20世纪初发现的一种脂溶性维生素,其经典作用是调节钙、磷代谢维持骨健康。近年,随着骨骼肌细胞中维生素D受体的发现,维生素D对骨骼肌健康的作用成为新的研究热点。研究认为,维生素D通过基因机制和非基因机制发挥作用。观察性研究发现,无论是普通人群还是运动员,其维生素D浓度与骨骼肌健康程度有关;但维持骨骼肌健康的最佳血清25(OH)D浓度还未确定。随机对照试验研究关于维生素D补充对骨骼肌形态、骨骼肌运动表现等的作用尚无定论,上肢和下肢不同肌群对维生素D补充的适应性反应存在差异,可能与维生素D受体浓度和基因多态性有关。此外,维生素D可能通过增加内源性睾酮,而具有增进身体机能的潜在作用,这在体育领域具有重要意义,但其机制还有待深入探讨。As a fat-soluble compound found in the 1920s, vitamin D is essential for bone health because of its classical role in regulation calcium and phosphorus homeostasis. In recent years, since vitamin D receptor was found in the skeletal muscle cells, the impact of vitamin D on skeletal muscle is becoming the new research focus. Researches suggest that vitamin D plays a role in maintaining skeletal muscle health through genetic and non-genetic mechanisms. It has been shown in observational studies that circulating vitamin D level is associated with skeletal muscle health, both in general population and athletes. However, the optimal serum 25 （OH） D concentration for main- taining skeletal muscle health has not been determined. Results from random control trials are no consensus on the effects of vitamin D supplementation on skeletal muscle form and function. And, it＇ s found that there may be different adaptive response on vitamin D supplementation between upper and lower limb muscle groups, which is probably attributed to the diversity of vitamin D receptor concentration and gene polymorphism. Several researches have also found that vitamin D perhaps have ergogenic potential through the enhancement of endogenous testosterone production, and the mechanism need to be further studied.

关 键 词：维生素D 骨骼肌 维生素D缺乏 肌肉功能 维生素D受体 雄性激素 

分 类 号：G804.2[文化科学—运动人体科学]