Activation of Parvalbumin-Positive Neurons in Both Retina and Primary Visual Cortex Improves the Feature-Selectivity of Primary Visual Cortex Neurons  

作　　者：Jinggang Duan Hang Fu Jiayi Zhang 

机构地区：[1]Institutes of Brain Science,State Key Laboratory of Medical Neurobiology,Collaborative Innovation Center of Brain Science,Fudan University,Shanghai 200032,China

出　　处：《Neuroscience Bulletin》2017年第3期255-263,共9页神经科学通报（英文版）

基　　金：supported by the grants of National Natural Science Foundation of China(31271158,31421091,and 31422025);the Science and Technology Commission of Shanghai Municipality,China(13PJ1401000);the Young 1000 Plan and the Ministry of Science and Technology of China(2015AA020512)

摘　　要：Several recent studies using either viral or transgenic mouse models have shown different results on whether the activation of parvalbumin-positive（PV~＋）neurons expressing channelrhodopsin-2（ChR2） in the primary visual cortex（V1） improves the orientation-and direction-selectivity of V1 neurons. Although this discrepancy was thoroughly discussed in a follow-up communication, the issue of using different models to express ChR2 in V1 was not mentioned. We found that ChR2 was expressed in retinal ganglion cells（RGCs） and V1 neurons in ChR2fl/~＋; PV-Cre mice. Our results showed that the activation of PV~＋RGCs using white drifting gratings alone significantly decreased the firing rates of V1 neurons and improved their direction-and orientation-selectivity. Longduration activation of PV~＋interneurons in V1 further enhanced the feature-selectivity of V1 neurons in anesthetized mice, confirming the conclusions from previous findings. These results suggest that the activation of both PV~＋RGCs and V1 neurons improves feature-selectivity in mice.Several recent studies using either viral or transgenic mouse models have shown different results on whether the activation of parvalbumin-positive（PV~＋）neurons expressing channelrhodopsin-2（ChR2） in the primary visual cortex（V1） improves the orientation-and direction-selectivity of V1 neurons. Although this discrepancy was thoroughly discussed in a follow-up communication, the issue of using different models to express ChR2 in V1 was not mentioned. We found that ChR2 was expressed in retinal ganglion cells（RGCs） and V1 neurons in ChR2fl/~＋; PV-Cre mice. Our results showed that the activation of PV~＋RGCs using white drifting gratings alone significantly decreased the firing rates of V1 neurons and improved their direction-and orientation-selectivity. Longduration activation of PV~＋interneurons in V1 further enhanced the feature-selectivity of V1 neurons in anesthetized mice, confirming the conclusions from previous findings. These results suggest that the activation of both PV~＋RGCs and V1 neurons improves feature-selectivity in mice.

关 键 词：Parvalbumin neurons Primary visual cortex Retinal ganglion cells Optogenetics 

分 类 号：R338[医药卫生—人体生理学]