Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice  

作　　者：Liming Chen Xinan Liu Hua Wang Min Qu 

机构地区：[1]Neurology Department,The First People's Hospital of Jingzhou,The First Affiliated Hospital of Yangtze University,Jingzhou 434000,China [2]Hubei Provincial Key Laboratory for Applied Toxicology,Hubei Provincial Center for Disease Control and Prevention,Wuban 430079,China [3]Department of Neuroscience,lcahn School of Medicine at Mount Sinai,New York,NY 10029,USA

出　　处：《Neuroscience Bulletin》2017年第3期264-272,共9页神经科学通报（英文版）

摘　　要：Gastrodin, the major component isolated from the rhizome of the Chinese traditional medicinal herb Gastrodia elata（‘‘Tianma＇＇）, has a long history in the treatment of epilepsy and other neurological disorders.However, the molecular mechanisms are not clear. Here,we found that gastrodin ameliorated pentylenetetrazole（PTZ）-induced epileptic seizures with improvement of the electroencephalographic pattern in mice. Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1b and tumor necrosis factor-a while increasing interleukin-10, an antiinflammatory cytokine in the brain. Furthermore, gastrodin attenuated the PTZ-induced microglial activation along with inhibition of mitogen-activated protein kinases,c AMP response element binding protein, and NF-j B. Our data suggest that gastrodin attenuates seizures by modulating the mitogen-activated protein kinase-associated inflammatory responses.Gastrodin, the major component isolated from the rhizome of the Chinese traditional medicinal herb Gastrodia elata（‘‘Tianma＇＇）, has a long history in the treatment of epilepsy and other neurological disorders.However, the molecular mechanisms are not clear. Here,we found that gastrodin ameliorated pentylenetetrazole（PTZ）-induced epileptic seizures with improvement of the electroencephalographic pattern in mice. Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1b and tumor necrosis factor-a while increasing interleukin-10, an antiinflammatory cytokine in the brain. Furthermore, gastrodin attenuated the PTZ-induced microglial activation along with inhibition of mitogen-activated protein kinases,c AMP response element binding protein, and NF-j B. Our data suggest that gastrodin attenuates seizures by modulating the mitogen-activated protein kinase-associated inflammatory responses.

关 键 词：Gastrodin Epilepsy IL-1b TNF-a IL-10 MAPK CREB NF-j B 

分 类 号：R285.5[医药卫生—中药学]