安胃汤治疗功能性消化不良寒热杂证的临床疗效观察  

The clinical observation of functional dyspepsia of syndrome of intermingled heat and cold with the treatment of Anwei Decoction

作　　者：朱永钦 刘玉[2] 朱永苹[1] 林寿宁[1] 黄连梅 奚锦要[1] 罗昭琼[1] 李岸平 曾文彬[3] 王潇晗 骆小霞[3] 黎瑩 吴承芳 陈保霖 

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011 [2]九江市第一人民医院,江西九江332000 [3]广西中医药大学,广西南宁530001

出　　处：《时珍国医国药》2017年第8期1934-1937,共4页Lishizhen Medicine and Materia Medica Research

基　　金：广西中医药民族医药传承创新专项立项课题(GZLC16-17);广西中医药民族医药自筹经费科研课题(GZZC15-19)

摘　　要：目的观察和评价安胃汤治疗功能性消化不良寒热错杂证的有效性及其对患者血浆胃动素和血清胃泌素水平的影响,为安胃汤的临床应用和科研开发提供新的依据。方法选取2015年06月至2016年06月期间在广西中医药大学附属瑞康医院消化内科住院和门诊就诊被诊断为功能性消化不良寒热错杂证的40例患者,按照随机数字表法分为治疗组和对照组,每组各20例,治疗组予服用中药安胃汤治疗,对照组予口服多潘立酮片联合复方阿嗪米特肠溶片治疗,两组患者均以2个月为1个疗程,连续治疗1个疗程后,分别分析比较两组患者的中医证候积分、临床疗效及血浆胃动素和血清胃泌素水平变化,并观察药物的安全性。结果两组患者经过1个疗程治疗后,治疗组总有效率是85.00%,对照组总有效率为75.00%,两组总有效率相比较差异具有统计学意义(P<0.05);两组患者治疗后胃脘痞满、嘈杂、疼痛等主症积分和纳呆、嗳气等次症积分与治疗前相比均有所下降,以治疗组最为显著,两组相比较差异具有统计学意义(P<0.05);治疗组能够显著提高患者血浆胃动素和血清胃泌素水平,与对照组相比较具有显著性差异(P<0.05);两组患者在用药期间均未出现不良反应,两组相比较差异不具有统计学意义(P>0.05)。结论 (1)安胃汤治疗功能性消化不良寒热错杂证临床疗效确切,安全性好,并且可以提高患者的血浆胃动素和血清胃泌素水平;(2)安胃汤治疗功能性消化不良寒热错杂证的作用机制可能与影响患者的血浆胃动素和血清胃泌素水平相关。Objective To observe and evaluate the effectiveness of Anwei Decoction treating the syndrome of intermingled heat and cold of functional dyspepsia and the influence of patients＇ plasma motilin level and serum gastrin lever,so that it can provide new evidence for Anwei Decoction in clinical application and scientific research and development. Methods 40 patients were selected from whom were diagnosed with syndrome of intermingled heat and cold of functional dyspepsia by Department of Gastroenterology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine outpatient and inpatient ward during Jun 2015 to Jun 2016. Divided them into treatment group and control group according to random number table method,20 cases in each group.The treatment group was treated with oral administration of Chinese herbal compound Anwei Decoction treatment,and the control group was treated with Domperidone Tablets combined with Compound Azintamide Enteric-coated Tablets treatment. Two groups of patients with 2 months for a period of treatment,continuous after one course of treatment,respectively,compared two groups of patients with symptoms integral,clinical curative effect and variation of plasma motilin and serum gastrin lever,and observed their safety. Results After one course of treatment,the treatment group effective rate was 85%,and the control group effective rate was 75%. The effective rate difference between two groups was statistically significant（ P〈0. 05）; After treatment,the primary symptom integral such as upper abdominal distension,gastric upset,pain and so on,and the secondary symptom integral such as anorexia,belching,were both decreased,and the treatment group was in more significant than the control group,also had statistically significant difference（ P〈0. 05）. The treatment group can significantly improve the level of plasma motilin and serum gastrin,compared with the control group with significant difference（ P〈0. 05）; Two groups of patients with no adverse reactions occurred during

关 键 词：安胃汤 功能性消化不良 寒热错杂证 胃动素 胃泌素 

分 类 号：R259[医药卫生—中西医结合]