人参中精氨酸双糖苷的研究进展  

Research progress of Arginyl-Fructosyl-Glucose in Panax ginseng

作　　者：高铭彤 李莹[1] 李婧毓 刘一桐 曾露露[1] 丁传波[1] 刘文丛[1] 郑毅男[1] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118

出　　处：《时珍国医国药》2017年第8期1979-1981,共3页Lishizhen Medicine and Materia Medica Research

基　　金：吉林省自然科学基金(No.20160101017JC);吉林省教育厅项目(No.吉教科合字[2016]第197号)

摘　　要：精氨酸双糖苷(AFG)是存在于红参中的一种有效成分,它属于一种精氨酸衍生物。综述近年来对精氨酸双糖苷的提取制备、合成、检测方法及药理作用的研究现况。AFG的制备是将红参放入甲醇溶液中超声提取3次,合并上清液得到红参水提物,通过聚丙烯酰胺凝胶柱和阳离子交换树脂达到了AFG的分离和纯化,精氨酸和麦芽糖通过酸性环境在加热情况下实现了人工合成,通过薄层扫描法和氨基酸自动分析仪对AFG的含量进行检测。同时精氨酸双糖苷还具有很强的药理活性,如抗氧化、抗炎和抗糖尿病等。Arginyl-Fructosyl-Glucose（ AFG） is a kind of effective ingredients in red Ginseng,it belongs to a kind of arginine derivatives. This article summarized the research progress of the preparation,synthesize methods,detection methods and pharmacological effects of arginyl-fructosyl-glucose in recent years. The preparation of the AFG is let red Ginseng into the methanol solution,ultrasonic extraction three times,and then,combined the supernatants,that＇s the red Ginseng water extraction. Using polyacrylamide gel column and cation exchange resin,it reached the separation and purification of AFG. Arginine and maltose by acid environment in the case of heating to achieve the artificial synthesis. AFG content detected via TLCS and automatic amino acid analyzer. AFG has a strong pharmacological activity,for example,anti-oxidation,anti-inflammatory and antidiabetic.

关 键 词：精氨酸双糖苷 人参 精氨酸衍生物 药理活性 药理机制 

分 类 号：R91[医药卫生—药学]