ACE2/Apelin信号在血管自噬调控和高血压发病中的作用  

Effects of ACE2/Apelin signaling on vascular autophagy regulation and hypertension pathogenesis

作　　者：张艳 程玉文[1] 钟久昌[1] 

机构地区：[1]上海市高血压研究所上海交通大学医学院附属瑞金医院医学基因组学国家重点实验室,上海200025

出　　处：《上海交通大学学报（医学版）》2017年第9期1260-1264,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81370362;81770253);国家重大研究计划资助项目(91339108);国家重点基础研究发展计划(2014CB542300);上海市教育委员会高峰高原学科建设计划(20152509)~~

摘　　要：自噬在维持正常血管结构功能中提供保护功效,但过度自噬可能导致高血压病等血管疾病的发病。血管自噬失衡参与高血压血管重构损伤的发生和发展,且与ACE2/Apelin信号表达或活性异常密切相关。该文主要对ACE2/Apelin信号参与血管自噬调控及其在高血压发病过程中的作用作一综述。Autophagy provides protective effects on the maintenance of normal vascular structure and fimction. However, an overactivation of autophagy contributes to the pathogenesis of hypertension and other vascular diseases. The imbalance of vascular autophagy is involved in the occurrence and development of hypertensive vascular remodeling and injury, which is closely related to abnormal expression or activity of ACE2/Apelin signaling. This review will focus on the latest advancement and regulatory roles of ACE2/Apelin signaling in vascular autophagy and the pathogenesis of hypertension.

关 键 词：高血压 肾素—血管紧张素系统 自噬 血管紧张素Ⅱ 

分 类 号：R544.1[医药卫生—心血管疾病]