赤芍总苷药理作用的研究进展  

Progress in pharmacological research of total paeony glycoside

作　　者：董国菊[1] DONG Guoju(Department of cardiology, Xiyuart Hospital, China Academy of Chinese Medical Science. Beijing 100091, China)

机构地区：[1]中国中医科学院西苑医院心血管科,北京100091

出　　处：《环球中医药》2017年第9期1157-1160,共4页Global Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金(81001517);国家自然科学基金面上基金(81273929)

摘　　要：赤芍总苷是赤芍的主要活性成分,其具体作用机制包括调节机体免疫状态、诱导肿瘤细胞凋亡、减少耐药蛋白和基因表达、抗血小板聚集、延长血栓形成时间、降低血液黏稠度、增强红细胞变形能力、抑制心肌细胞凋亡、清除氧自由基、稳定心肌细胞膜、增加脑血流量、保护脑细胞,减轻肝损害、保护肝细胞、抗抑郁和稳定斑块等。本文就近10年来赤芍总苷的药理作用进展做一总结。Total paeony glycoside （TPG）is the main active ingredients of Radix paeoniae rubra. The pharmacological mechanisms includes regulating the immune state, inducing apoptosis of tumor cells, reducing the drug resistance-protein and gene expression, anti platelet aggregation, prolonging thrombosis time, reducing blood viscosity, increasing the erythrocyte deformability, inhibiting the apoptosis of myocardial ceils, scavenging oxygen free radicals, stabilizing myocardial cell membrane, increasing the protection of cerebral blood flow, protecting brain cells, reducing liver damage, protecting liver cells, anti depression and stabilizing plaque This paper made a summarization of pharmacological progress of TPG in recent 10 years.

关 键 词：赤芍总苷 药理作用 多效性 

分 类 号：R285[医药卫生—中药学]