血清Ig、CRP联合肺功能检测在RMPP诊治中的应用  

Study on application of serum immunoglobulin and CRP levels and lung function detection in diagnosis and treatment of RMPP

作　　者：熊维 钱柯 伍剑[3] Xiong Wei Qian Ke Wu Jian(Department of Pediatrics ,Youyang County People＇s Hospital ,Chongqing 409800 ,China Jiangyang District Women and Children＇ s Hospital, Luzhou, Sichuan 646000, China Department of Pediatrics ,Chongqing Municipal Ninth People＇s Hospital, Chongqing 400700, China)

机构地区：[1]重庆市酉阳县人民医院儿科,409800 [2]四川省泸州市江阳区妇女儿童医院,646000 [3]重庆市第九人民医院儿科,400700

出　　处：《重庆医学》2017年第27期3822-3824,共3页Chongqing medicine

摘　　要：目的探讨血清免疫球蛋白(Ig)、C反应蛋白(CRP)和肺功能检测在儿童难治性肺炎支原体肺炎(RMPP)诊治中的应用价值。方法选取2015年1月至2016年6月3家医院收治的RMPP患儿82例为肺炎组,以基线资料匹配的同期体检健康儿童30例为对照组。比较两组血清IgA、IgG、IgM、IgE和CRP水平及同期1s用力呼气容积(FEV1)、用力肺活量(FVC)等肺功能指标,分析其在RMPP诊断中的应用价值。结果与对照组比较,肺炎组血清IgA、IgG水平、FEV1和FVC均降低,血清IgE和CRP水平均升高(P<0.05)。与治疗前比较,肺炎组治疗后的血清IgA、IgG水平、FEV1和FVC均升高,血清IgE和CRP水平均降低(P<0.05)。治疗前后肺炎组治疗无效患儿的血清IgA、IgG水平、FEV1和FVC均低于治疗有效患儿,血清IgE和CRP水平则高于治疗有效患儿(P<0.05)。RMPP患儿血清IgA、IgG、IgE、CRP水平与FEV1、FVC和治疗有效率均相关。结论血清Ig、CRP水平及肺功能检测在儿童RMPP诊断中具有较大应用价值,值得在临床推广应用。Objective To investigate the application value of serum immunoglobulin（Ig） and C-reactive protein（CRP） and lung function detection in the diagnosis and treatment of child refractory mycoplasma pneumoniae pneumonia（RMPP）. Methods Eighty-two cases of child RMPP treated in these 3 hospitals from January 2015 to June 2016 were selected as the pneumonia group and contemporaneous 30 baseline data matched children undergoing physical examination served as the control group. The levels of serum IgA,IgG,IgM,IgE and CRP, forced expiratory volume at 1 s （FEV1）, forced vital capacity （FVC） and other pulmonary function indexes were compared between the two groups. Their application value in diagnosis was analyzed. Results Compared with the control group, serum IgA and IgG levels, FEV1 and FVC in the pneumonia group were decreased, while serum IgE and CRP levels were increased （P〈0.05）. Compared with before treatment, serum IgA and IgG levels, FEV1 and FVC after treatment in the pneumonia group were increased, while serum IgE and CRP levels were decreased（P〈0.05）. Serum IgA and IgG levels, FEV1 and FVC before and after treatment in the ineffective cases of the pneumonia group were lower than those in the effective cases, while serum IgE and CRP levels were higher than those in the effective cases （P〈0.05）. Serum IgA,IgG,IgE and CRP levels in children cases of RMPP were related to FEV1 and FVC level and treatment effective rate. Conclusion Serum IG,CRP and lung function detection has larger application value in diagnosing child RMPP and is worth clinical promotion.

关 键 词：免疫球蛋白 C反应蛋白 儿童 难治性肺炎支原体肺炎 肺功能 

分 类 号：R725.6[医药卫生—儿科]