P2X_7受体在组织纤维化中的作用  

Role of P2X_7 receptors in tissue fibrosis

作　　者：徐珍 张玉芹[2] 彭勇 XU Zhen ZHANG Yu-qin PENG Yong(Department of Critical Care Medicine, Wuhan Red Cross Hospital, Wuhan Hubei,430015,China Department of Physiology, Medical College, Wuhan University of Science and Technology, Wuhan Hubei, 430065,China)

机构地区：[1]武汉市红十字会医院重症医学科,湖北武汉430015 [2]武汉科技大学医学院生理学教研室,湖北武汉430065

出　　处：《职业与健康》2017年第16期2301-2304,共4页Occupation and Health

基　　金：湖北省自然科学基金(2004ABA152);湖北省教育厅重点项目(D20081108)

摘　　要：嘌呤受体P2X家族是三磷酸腺苷(ATP)门控的选择性阳离子通道,对Na^+,K^+,Ca^(2+)都有通透性。与其他离子型配体门控通道受体相区别的是,P2X_7受体兼具"离子通道"和"孔道"功能。许多先前的研究证明了P2X_7受体(P2X7Rs)在不同的病理条件下有多种功能,包括参与机体免疫反应、神经递质释放、氧化应激及细胞增殖和凋亡等,可以作为用于治疗一系列疾病的靶点。尤其是最近的研究探讨了P2X_7受体在纤维化中的作用,而纤维化是大多数慢性炎症疾病的病理结果。作者主要探讨P2X_7受体的生物学特性和总结P2X_7受体引发器官例如肺、肾脏、肝脏、胰腺和心肌广泛纤维化中假定的角色作用。P2X receptor family is adenosine triphosphate（ATP）-gated selective cation channel,with the permeability for Na~＋,K~＋and Ca^（2＋）. Compared with other ionotropic ligand gated channel receptor,P2X_7 receptor has the function of ion channel and hole.Previous studies have proved that P2X_7receptors（P2X_7Rs） have many functions in different pathological conditions,including immune response,neurotransmitter release,oxidative stress,cell proliferation and apoptosis,which can be used as a target to cure a series of diseases. Especially the recent study has discussed the role of P2X_7 Rs in tissue fibrosis which is the pathological result of chronic inflammatory diseases. The authors discuss the biological characteristics of P2X_7 Rs,and summarize the assumed role of P2X_7 Rs in causing the extensive fibrosis of organs such as lung,kidney,liver,pancreas and myocardium.

关 键 词：P2X_7受体 三磷酸腺苷 炎症 纤维化疾病 

分 类 号：R181.32[医药卫生—流行病学]