ACE基因多态性与维吾尔族异常黑胆质型高血压病的相关性  

Association between angiotensin converting enzyme gene polymorphism and hypertension with abnormal savda in Uyghur people

作　　者：雪合热提·伊纳也提 卡思木江·阿西木江[2] 吴桂霞 阿不来提·阿合买提[2] 张景萍[2] 钟莉[2] 库热西·玉努斯[2] Xuehereti Yinayeti Kasimujiang Aximujiang Gui-Xia Wu Abulaiti Ahemaiti Jing-Ping Zhang Li Zhong Kurexi Yunusi(Department of Physiology, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, Chin)

机构地区：[1]新疆医科大学基础医学院生理学教研室,新疆维吾尔自治区乌鲁木齐市830011 [2]新疆医科大学基础医学院生物化学教研室,新疆维吾尔自治区乌鲁木齐市830011

出　　处：《世界华人消化杂志》2017年第24期2209-2213,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目,No.81460751~~

摘　　要：目的探讨维吾尔族血管紧张素转化酶(angioten-sin converting enzyme,ACE)基因插入/缺失(insertion/deletion,I/D)多态性与异常黑胆质型高血压病的关系.方法将维吾尔族不同异常体液人群138例分成异常黑胆质型高血压组和非异常黑胆质型高血压组,采用聚合酶链反应-限制性片断长度多态性技术进行I/D位点多态性检测.结果异常黑胆质型高血压组和非异常黑胆质型高血压组基因型分布ID、II和DD分别为68.33%、23.33%、8.34%和64.10%、11.54%、24.36%,差异有统计学意义(P<0.05);异常黑胆质型高血压组等位基因I、D频率为57.5%、42.5%,而非异常黑胆质型高血压组为43.6%、56.4%,差异有统计学意义(P<0.05).结论 ACE基因ID、II基因型及I等位基因可能是维吾尔族异常黑胆质型高血压病发病的遗传危险因素之一.AIM To investigate the association of the insertion/deletion（I/D） single nucleotide polymorphism of the angiotensin converting enzyme（ACE） gene with hypertension with abnormal savda in Uyghur people.METHODS One hundred and thirty-eight Uyghur people with hypertension were divided in two groups： those with abnormal savda and those with non-abnormal savda. The I/D single nucleotide polymorphism of the ACE gene was genotyped by polymerase chain reaction-restriction fragment length polymorphism.RESULTS In the abnormal savda group, the frequencies of ID, II, and DD genotypes were 68.33%,23.33%, and 8.34%, respectively, and 64.10%, 11.54%, and 24.36%, respectively, in the non-abnormal savda group. There were significant differences in the frequencies of ID, II, and DD genotypes between the two groups. The frequencies of allele I and allele D was 57.5% and 42.5%, respectively, in the abnormal savda group, and 43.6% and 56.4%, respectively, in the non-abnormal savda group. There were significant differences in the frequencies of the two alleles between the two groups.

关 键 词：血管紧张素转化酶 基因多态性 高血压 异常黑胆质型体液 

分 类 号：R29[医药卫生—民族医学]