大疱性类天疱疮180抗体阳性的寻常型天疱疮3例  

Three cases of phemphigus vulgaris with anti-Bp180 antibody positive

作　　者：孙景英[1] 刘建勇[2] 普雄明[2] 杨森[1] 张学军[1] 

机构地区：[1]安徽医科大学皮肤病研究所安徽医科大学第一附属医院皮肤性病科,安徽合肥230032 [2]新疆维吾尔自治区人民医院皮肤病与性病科,新疆乌鲁木齐830001

出　　处：《临床皮肤科杂志》2017年第10期709-712,共4页Journal of Clinical Dermatology

摘　　要：报告3例大疱性类天疱疮(BP)180抗体阳性的寻常型天疱疮患者。所有患者均以口腔、外阴黏膜糜烂,躯干多发水疱逐渐加重就诊。皮肤科检查:患者分别在头皮、面部、颈部、口腔、外阴、躯干及下肢等部位出现绿豆至花生米大的孤立或融合性水疱,部分糜烂面潮湿。实验室检查:血清检测抗桥粒芯糖蛋白(Dsg)抗体和Bp180抗体均阳性,直接免疫荧光(DIF)示抗棘细胞桥粒抗体(PCDA)阳性或抗表皮基膜抗体(EBA)阳性。皮损组织病理检查:表皮内水疱,棘细胞松解,基底呈"绒毛"样改变,基底层见中量淋巴细胞浸润。结合临床及实验室检查诊断为BP180抗体阳性的寻常型天疱疮。Three cases of phemphigus vulgaris with positive anti-BP180 antibody are reported. These patients presented with oral and genital mucosal erosion, and aggravating blisters on the trunk. Physical examination showed isolated and merged blis- ters sized from green bean to peanut on the scalp, face and neck, mouse, external genitalia, chest, back and lower limbs. Some blisters were with erosion. Laboratory tests showed positive for both serum anti-desmoglein（Dsg） and anti-BP180 ant/- body. Direct immunofluorescence（DIF） showed positive for PCDA or EBA antibody. Pathological examination revealed intraepi- dermal blisters, acantholysis, formation of villi by basal cells and lymphocytic infiltrate of the basal layer. Combined the clini- cal features with laboratory results, these patients were diagnosed of phemphigus vulgaris with anti-BPplS0 antibody positive.

关 键 词：天疱疮 寻常型 BP180 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]