姜酚在心血管疾病中的药理作用研究进展  

Research progress on pharmacological actions of gingerols in cardiovasular disease

作　　者：吴英智[1] 傅强[1] 严全能[1] 李志樑[1] 

机构地区：[1]南方医科大学珠江医院心血管内科,广州510280

出　　处：《中国临床药理学杂志》2017年第18期1824-1827,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81573732);广东省自然科学基金资助项目(2015A030313304)

摘　　要：姜酚是姜中重要活性成分,6-姜酚则是姜酚中的主要成分。国内外学者对姜酚及其同系物的分子结构、药理作用做了大量研究,证实其具有抗炎、抗氧化、降压、强心、抗血小板、降血脂、抗动脉粥样硬化等心血管药理作用。姜酚通过抑制炎症因子、血管紧张素Ⅱ活性、血小板环氧合酶活性、血栓素合成、晚期糖基化终末产物形成,促进心肌肌浆网Ca^(2+)-ATP酶活性,调节血脂代谢过程中相关酶蛋白的表达等途径发挥上述药理作用。本文主要介绍近年来姜酚在心血管疾病方面药理作用机制的研究进展。Gingerols are the important active compounds in ginger（ Zingiber ocinale Roscoe,Zingiberacae）,and 6-gingerol is the main compound of gingerols. Chinese and foreign scholars have done a lot of studies on the molecular structure and pharmacological effects of gingerols and its homologues,which confirmed that gingerols have cardiovascular pharmacological effects of anti-inflammatory,anti-oxidative,anti-hypertensive,cardiac,anti-platelet,hypolipidemic,anti-atherosclerosis and so on. Gingerols play the above pharmacological effects by inhibiting the inflammatory factors,angiotensin Ⅱ activity,cyclooxygenase activity,thromboxane synthesis,the production of advanced glycation end-products; promoting the activity of myocardial sarcoplasmic reticulum Ca^（2＋）-ATPase; regulating relate enzyme expression during the process of lipid metabolism and other ways. This article mainly reviews the recent progress in the pharmacological mechanism of gingerols in cardiovascular diseases.

关 键 词：姜酚 抗氧化 抗血小板 抗动脉粥样硬化 

分 类 号：R28[医药卫生—中药学]