清利活血养阴方治疗慢性肾小球肾炎临床研究  

Clinical Study on Qingli Huoxue Yangyin Prescription in Treatment of Chronic Glomerulonephritis

作　　者：张之惠 ZHANG Zhihui(The First Affiliated Hospital to Sooehow University,Suzhou Jiangsu China 215006)

机构地区：[1]苏州大学附属第一医院,江苏苏州215006

出　　处：《中医学报》2017年第9期1753-1756,共4页Acta Chinese Medicine

基　　金：江苏省中医药科技攻关项目(L211094)

摘　　要：目的:观察中西医结合治疗慢性肾小球肾炎(chronic glomerulonephritis,CGN)的临床疗效。方法:将48例确诊为CGN患者随机分为对照组(24例)、观察组(24例)。对照组给予传统肾病治疗方案,观察组在对照组治疗基础上加服清利活血养阴方。比较两组患者临床疗效、中医证候积分、肾功能[24小时尿蛋白定量(24 hour urine total protein,24h UTP)、内生肌酐清除率(endogenous creatinine clearance rate,Ccr)、血尿素氮(blood urea nitrogen,BUN)]、肝功能、血常规、血脂指标及炎症因子[肿瘤坏死因子-α(tumor necrosis factor alpha,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-1β(interleukin-1 beta,IL^(-1)β)和C-反应蛋白(C-reactive protein,CRP)]。结果:观察组证候积分、有效率分别为(10.50±3.94)分、91.67%,对照组分别为(14.70±4.21)分、66.67%,两组比较,差异均有统计学意义(P<0.05)。观察组治疗后24h UTP、Scr、BUN分别为(0.68±0.31)g、(86.17±20.93)μmol·L^(-1)、(5.07±1.44)mmol·L^(-1),对照组分别为(0.93±0.32)g、(85.50±22.68)μmol·L^(-1)、(5.62±1.54)mmol·L^(-1),两组比较,差异均有统计学意义(P<0.05)。观察组治疗后TNF-α、IL-6、IL^(-1)β、CRP分别为(25.47±5.29)ng·L^(-1)、(7.50±1.05)ng·L^(-1)、(2.05±0.97)pg·L^(-1)、(7.13±1.10)ng·L^(-1),对照组以上指标分别为(20.14±5.18)ng·L^(-1)、(6.22±0.98)ng·L^(-1)、(1.17±0.84)pg·L^(-1)、(6.00±0.94)ng·L^(-1),两组比较,差异均有统计学意义(P<0.05)。结论:清利活血养阴方加西药基础治疗慢性肾小球肾炎,能够减少尿蛋白,改善肾功能,疗效显著且安全可靠。Objective： To observe the clinical curative effect of Integrative medicine on Chronic glomerulonephritis（ CGN）. Methods： Forty-eight patients with CGN were randomly divided into control group（ 24 cases） and observation group（ 24 cases）. The control group was given traditional kidney disease treatment,while the observation group was treated with Qingli Huoxue Yangyin Prescription in addition to that of the control group. The Clinical efficacy,TCM syndrome scores,renal function（ 24 hur urine total protein）,levels of endogenous creatinine clearance（ Ccr）,blood urea nitrogen（ blood urea nitrogen） were significantly higher than those in the control group（ P〈0. 05）（ TNF-α）,interleukin-6（ IL-6）,Interleukin-1 beta and C-reactive protein of both groups were compared. Results： After treatment,the scores of syndrome of the observation group was（ 10. 50 ± 3. 94） which was significantly lower than that（ 14. 70 ± 4. 21） of the control group（ P〈0. 05）. The clinical efficacy rate of the observation group was 91. 67% respectively,which was significantly higher than that（ 66. 67%） of the control group respectively（ P〈0. 05）. The levels of 24 h UTP,Scr and BUN of the observation group were（ 0. 68 ± 0. 31）（ 86. 17 ± 20. 93） and（ 5. 07 ± 1. 44） respectively,and those of the control group were（ 0. 93 ± 0. 32） g,（ 85. 50 ± 22. 68） umol·L-1and（ 5. 62 ± 1. 54） mmol·L-1respectively,the differences between the both groups were statistically significant（ P〈0. 05）. After treatment,TNF-α,IL-6,IL-1β and CRP of the observation group were（ 25. 47 ± 5. 29） ng·L-1,（ 7. 50 ±1. 05） ng·L-1,（ 2. 05 ±0. 97） pg·L-1and（ 7. 13 ± 1. 10） ng·L-1,and those of the control group were（ 20. 14 ± 5. 18） ng·L-1,（ 6. 21 ± 0. 98） ng·L-1,（ 1. 17 ± 0. 84） pg·L-1,and（ 6. 00 ±0. 94） ng·L-1respectively,the differences were statistically significant（ P〈0. 05）. Conclusion： The treatment of chronic glomerulonep

关 键 词：慢性肾小球肾炎 清利活血养阴方 肾功能 肝功能 中西医结合 

分 类 号：R277.592.31[医药卫生—中医学]