中医药防治阿尔茨海默病与Wnt/β-catenin信号通路作用研究述评  

Research Review of Prevention and Treatment of Alzheimer's Disease with Traditional Chinese Medicine and role of Wnt/β-catenin Signaling Pathway

作　　者：宋军营[1] 李春花[1] 袁永[1] 闫敏[1] 张钟允[1] 刘文第[1] 高爱社[1] 张振强[1] SONG Junying LI Chunhua YUAN Yong YAN Min ZHANG Zhongyun LIU Wendi GAO Aishe ZHANG Zhenqiang(Henan University of Chinese Medicine, Zhengzhou Henan China 45004)

机构地区：[1]河南中医药大学,河南郑州450046

出　　处：《中医学报》2017年第9期1761-1765,共5页Acta Chinese Medicine

基　　金：国家自然科学基金项目(U1504829);河南省科技攻关计划项目(14230041023);河南省自然科学基金项目(162300410127;16102310182)

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是一种中枢神经系统退行性疾病,以记忆力减退和认知障碍为主要表现。经典Wnt信号通路是重要的信号转导通路之一,调节多种靶基因的转录、翻译,参与中枢神经系统发育的过程。Wnt/β-catenin信号通路参与多种神经系统发育过程的调节,包括突触发生及功能形态变化,神经细胞的增值分化等。Wnt/β-catenin信号通路在AD发生机制中起到非常重要的作用。近年来研究发现,中医药对Wnt/β-catenin信号通路具有调节作用,中医药具有多成分、多靶点的优势,多种中药及复方、单体具有保护神经血管单元的作用,主要是通过调节Wnt/β-catenin信号通路中的关键信号分子Wnt3a、Axin2、GSK-3β、Wnt7b、β-catenin、TCF4、Fiz9等蛋白的表达发挥作用。这对探讨AD的发病机制及中医药防治的作用机制提供理论基础。The main symptoms of Alzheimer＇s disease,which is a degenerative disease of the central nervous system,are memory and cognitive impairment. WNT signal pathway is one of the important signal transduction pathways,regulating a variety of target gene＇s transcription and translation,and participating in the central nervous system＇ s development process. The Wnt/β-catenin signaling pathway is involved in the regulation of various neurological development processes,including synaptogenesis and functional morphological changes,and the differentiation of nerve cells. The Wnt/β-catenin signaling pathway plays a very important role in the AD mechanism. Recently,it has been found that Chinese medicine has a moderating effect on Wnt/β-catenin signaling pathway. Chinese medicine has the advantages of multi-component and multi-target. Besides,many kinds of traditional Chinese medicine and compound have the effect of protecting nerve vessel units,mainly by regulating Wnt/β-Catenin signaling pathway in the key signaling molecules Wnt3 a,Axin2,GSK-3β,Wnt7 b,β-catenin,TCF4,Fiz9 and other protein expression. This is a theoretical basis for discussing the pathogenesis of alzheimer＇s disease and the role of Chinese medicine in the prevention and treatment of alzheimer＇s disease.

关 键 词：阿尔茨海默病 WNT/Β-CATENIN 中医药治疗 

分 类 号：R259.491.6[医药卫生—中西医结合]