PVC梳状接枝共聚物载药微球的制备与表征  

Preparation and characterization of drug-loading microspheres made from comb-shaped PVC graft copolymers

作　　者：隋璐璐 张硕 陈韵如 李娟[1] 孙钰洁 张洁 牛永盛[1] SUI Lulu ZHANG Shuo CHEN Yunru LI Juan SUN Yujie ZHANG Jie NIU Yongsheng(College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China)

机构地区：[1]青岛农业大学化学与药学院,山东青岛266109

出　　处：《聚氯乙烯》2017年第9期25-27,41,共4页Polyvinyl Chloride

基　　金：国家自然科学基金资助项目(51003051)~~

摘　　要：通过点击化学反应,制备了PVC/单甲氧基聚乙二醇梳状接枝共聚物(PVC-g-MPEG),采用SEM观察了其微观结构,测定了以PVC-g-MPEG为载药微球、四氢呋喃为溶剂时毒死蜱的载药量、包封率,考察了以乙醇为溶剂时载药微球中毒死蜱的缓释性能。结果表明:(1)PVC-g-MPEG经剪切乳化后形成了不规则的粒径约1μm的微球;(2)毒死蜱的载药量为49%,包封率为75%;(3)毒死蜱缓释时间达到5.5 h,累积释放量为95%;(4)PVC-g-MPEG的缺点是既不溶解于有机溶剂,也不可降解。Polyvinyl chloride/monomethoxy-polyethylene glycol comb-shaped graft copolymers （PVC-g-MPEG） were prepared by click chemistry reaction. The microstructure ofPVC-g-MPEG mi- crospheres was observed by SEM. Loading capacity and entrapment efficiency of chlorpyrifos were de- termined under the cofiditons of using PVC-g-MPEG as drug-loading microspheres and using THF as solvent. The sustained-release properties of chlorpyrifos in drug-loading microspheres were investigated. The results showed that PVC-g-MPEG was sheared and emulsified to irregular microspheres with a di- ameter of about 1 μm. Loading capacity and entrapment efficiency of chlorpyrifos were 49% and 75% , respectively. Sustained-release time and accumulative release percentage of chlorpyrifos were 5.5 h and 95% , respectively. The defect of PVC-g-MPEG was that it neither dissolved in organic solvents nor was degradable.

关 键 词：PVC 点击化学 载药量 包封率 载药微球 

分 类 号：TQ460.1[化学工程—制药化工]