非高密度脂蛋白胆固醇水平与冠状动脉病变严重程度的相关性分析  

CORRELATION OF NON-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVELS AND CORONARY ARTERY LESION SEVERITY

作　　者：孙文栋[1] 孔令阁[2] Sun Wendong Kong Lingge(Inner Mongolia University for Nationalities, Tong Liao 028000 ,Chin)

机构地区：[1]内蒙古民族大学,内蒙古通辽市028000 [2]内蒙古民族大学第二临床医学院心血管内科

出　　处：《中国煤炭工业医学杂志》2017年第7期785-788,共4页Chinese Journal of Coal Industry Medicine

基　　金：内蒙古民族大学自然科学研究项目(编号:NMD1352)

摘　　要：目的探讨非高密度脂蛋白胆固醇(非HDL-C)与冠状动脉病变严重程度的关系。方法选取内蒙古民族大学第二临床医学院心内科2014年6月—2015年6月经选择性冠脉造影诊断为冠心病的住院患者为研究对象,以同期同科非CHD患者为对照组,根据冠状动脉造影结果将患者分为CHD组(A组)与对照组(B组),按Gensini积分分为三组轻度A1≤16(n=82)、中度17≤A2≤40(n=78)、重度A3>40(n=82);按病变累及冠脉支数分为单支病变组n1(n=110)、双支病变组n2(n=70)、三支病变组n3(n=62),收集各组临床一般资料、生化资料和冠状动脉造影结果,按照公式非HDL-C=TC-HDL计算非HDL-C值,并进行统计学分析。结果 (1)与B组相比,A组高血压病史比例、糖尿病病史比例、年龄、TC、HDL-C、非HDL-C、TG、UA、Scr、Fig水平明显升高,差异有统计学意义(P<0.05)。(2)在A1、A2、A3组,TC、非HDL-C、UA随病变程度加重呈升高趋势,但差异无统计学意义;n1,n2.n3组TC、非HDL-C水平随着病变累及支数增加而增加,并且有统计学意义(P<0.05)。(3)Spearman等级相关分析显示:TC、非HDL-C、TG、UA、LP(a)与Gensini积分呈正相关。结论非HDL-C与CHD关系密切,可作为CHD发病风险的一项预测指标,并且与单独一项血脂指标对比,对CHD患者的冠状动脉病变严重程度有较好的相关性。Objective To analyze the relationship of non-high-density lipoprotein cholesterol with coronary heart disease and coronary artery lesion severity.Methods We enrolled patients with CHD hospitalised in author’s hospital from Jun2014 to Jun2015.The non-CHD patients hospitalised in the same center during the same period served as control groups.We collected the clinical data and the results of coronary angiography and performed statistical analysis on the coronary lesion features.According to the coronary angiography（CAG）results,the patients were divided into coronary heart disease（CHD）group（group A）and non CHD group（group B）,including coronary heart disease group.According to the Gensini score results divided into mild（group A1）,moderate（group A2）,and severe（group A3）disease group.According to the number of diseased coronary branches were divided into single（group n1）,double（group n2）,triple（group n3）vessel disease group.We collected the clinical data and the results of coronary angiography and performed statistical analysis on the coronary lesion features.Depending on the formula of non-HDL-C=TC-HDL calculation of non-HDL-C values,and statistical analysis.Results Compared with group A and group B,number of patients with hypertension and T2 Ab,the age,the levels of TC,HDL-C,non-HDL-C,TG,UA,Scr,Fig increased（P〈0.05）.The levels of TC,non-HDL-C,UA in group A2 and A3 were higher than group A1,but P〉0.05.The levels of TC,non-HDL-C in group A2 and A3 were higher than group A1 and P〈0.05.Serum lipid levels and coronary severity（Gensini Points）：Gensini score was positively correlated with TC,non-HDL,TG,UA,LP（a）.Conclusion Non-high-density lipoprotein cholesterol and coronary heart disease are closely related.Compared with the lipids individual indicators,a high correlation with severity of cor onary artery disease in patients with coronary heart disease.

关 键 词：冠心病 非高密度脂蛋白胆固醇 

分 类 号：R543.3[医药卫生—心血管疾病]