检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:张海玲[1] 汪海涛[1] 杨文浩[2] 崔刘福[2] 张杰[1] 蒋晓忠[1] ZHANG Hailing WANG Haitao YANG Wenhao CUI Liufu ZHANG Jie JIANG Xiaozhong(Department of Gastroenterology, Kailuan General Hospital, Tangshan 863000, China Department of Rheumatology, Kailuan General Hospital, Tangshan 863000, China)
机构地区:[1]河北省唐山市开滦总医院消化内科,唐山063000 [2]河北省唐山市开滦总医院风湿免疫科,唐山063000
出 处:《福建医科大学学报》2017年第4期234-239,共6页Journal of Fujian Medical University
摘 要:目的探讨不同血尿酸水平与动脉硬化早期指标颈动脉内中膜厚度(cIMT)之间的关系。方法采用随机按年龄分层抽样方法,抽取≥40岁的某矿场工人5 440例,按照血尿酸水平进行分组,多因素分析血尿酸与cIMT的关系。结果 (1)5 294例研究对象纳入统计分析,非高尿酸组4 739例(89.5%),高尿酸组555例(10.5%)。(2)高尿酸组的年龄、cIMT、体质量指数(BMI)、收缩压(SBP)、对数转换后的甘油三酯(Log-TG)、总胆固醇(TC)、肌酐(Cr)的均值和饮酒、喜盐、锻炼比例均高于非高尿酸组,差别有统计学意义(P<0.05)。(3)多因素线性回归模型分析显示,校正相关因素后,血尿酸每增加1mg/dL,cIMT增加分别为:总人群0.01mm(95%CI:0.01~0.01,P<0.05),女性0.03 mm(95%CI:0.02~0.04,P<0.05),男性0 mm(95%CI:0.00~0.01,P=0.072)。(4)多因素Logistic回归分析结果显示,校正相关因素后,高尿酸组cIMT≥1mm的风险是非高尿酸组的倍数分别为:总人群是1.27倍(95%CI:1.01~1.60,P<0.05)、女性是1.99倍(95%CI:1.29~3.06,P<0.05)、男性是1.06倍(95%CI:0.81~1.39,P=0.67)。结论女性的血尿酸水平与cIMT增厚有关,高尿酸血症可能更易发生动脉硬化。Objective To investigate the relationship between serum uric acid level and carotid intima media thickness as an early indicator of arterial stiffness.Methods A total of 5 440 cases of a mine workers aged ≥40 years were randomly divided into two groups according to the level of serum uric acid.The relationship between serum uric acid and cIMT was analyzed by multivariate analysis.Results (1)5 294 participants were included in the study:non-hyperuricemia group 4 739 cases (89.5%),hyperuricemia group 555 cases (10.5%).(2) Mean age,cIMT,BMI,SBP,Log-TG,TC,Cr levels,and percentage of drinking,high salt diet,and extent of exercise in the hyperuricemia group were higher than those in the non-hyperuricemia group and he difference was statistically significant(P〈0.05).(3) Multiple linear regression showed that as serum uric acid increased by 1mg/dL after adjustment for relevant factors,carotid intima-media thickness increased in the following fashion:general population 0.01 mm (95%CI 0.01-0.01,P〈0.05),women 0.03 mm (95%CI 0.02-0.04,P〈0.05).and men 0.00 mm (95%CI 0.00-0.01,P=0.072),respectively.(4) Logistic multivariate regression analysis showed that after adjustment for relevant factors,the risk of cIMT≥1 mm in the hyperuricemia group was higher than that in the non-hyperuricemia group.The ORs were 1.27 (95%CI 1.01-1.60,P〈0.05) in all participants,1.9 (95%CI 1.29-3.06,P〈0.05) in female participants,1.06 (95%CI 0.81-1.39,P=0.67) in male participants.Conclusions In women the level of serum uric acid is related to carotid intima media thickening,and hyperuricemia may more likely lead to develop atherosclerosis.
分 类 号:R54[医药卫生—心血管疾病] R589.7[医药卫生—内科学]
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.229