老年高血压患者血管弹性和红细胞携氧能力与其心肺功能和生活质量关系  

Relationship between vessel elasticity,erythrocyte oxygen carrying capacity and heart/lung function and quality of life in elderly patients with hypertension

作　　者：蔡晗 刘刚[3] 陈欣 CAI Han LIU Gang CHEN Xin(Graduate, School, Tianjin Medical University, Tianjin 300070 China Personnel Section, Tianjin Chest Hospital, Tianjin 300222 China Department of Anesthesiology, Chinese PLA Army General Hospital, Beijing 100700 China Department of Mathematics, School of Public Heahh,Tianjin Medical University, Tianjin 300070, China)

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市胸科医院人事科,天津300222 [3]中国人民解放军陆军总医院麻醉科,北京100700 [4]天津医科大学公共卫生学院数学教研室,天津300070

出　　处：《天津医科大学学报》2017年第5期437-441,共5页Journal of Tianjin Medical University

摘　　要：目的:探讨老年高血压患者的血管弹性和红细胞携氧量与其心肺功能和生活质量的关系。方法:随机选择100名老年受试者分为两组:观察组为老年高血压患者(50例);对照组为相对健康的老年人(50例)。对比两组:(1)血管弹性指标:大动脉和小动脉的弹性指数、动脉血管顺应性、血管僵硬度以及血管壁厚度;(2)红细胞血氧能力指标:测定血氧饱和度50%时的氧分压(P50),用ELISA检测患者红细胞内2,3-二磷酯甘油酸(2,3-DPG)及丙酮酸激酶(PK)含量;(3)心脏功能检测:主动脉直径、左房内径、左室舒张内径、右房内径、右室内径、肺动脉内径、左室射血分数、室间隔厚度、左室后壁厚度及左室前壁厚度;(4)静态肺功能检测:潮气量、每分钟通气量、肺活量、最大通气量、第1秒用力呼气量、第1秒率及深吸气量;(5)采用生存质量核心问卷(QLQ-C30)对患者进行生存质量评估。对检测结果进行统计学分析。结果:对照组大、小动脉弹性指数均明显高于观察组(P<0.05);对照组血管顺应性明显高于观察组(P<0.05);而观察组血管僵硬度则明显高于对照组(P<0.05);观察组动脉内膜中层厚度大于对照组(P<0.05);观察组动脉脉搏波速高于对照组(P<0.05)。观察组外周血P50高于对照组(P<0.05);观察组外周血2,3-DPG和PK含量均高于对照组(P<0.05)。对照组主要心肺功能指标均优于观察组(P<0.05);观察组在躯体、角色、认知、情绪、社会等方面功能和整体生活质量各项指标评分均明显低于对照组(P<0.05)。结论:老年高血压患者动脉血管弹性降低、红细胞携氧能力下降,由此会进一步造成患者心肺功能的下降和生活质量的降低。Objective ：To detect the relationship between vessel elasticity,erythrocyte oxygen carrying capacity and heart/lung function and quality of life. Methods ：A hundred subjects were randomly selected and divided into two groups： Observer group of elderly patients with hypertension （n=50）; control group of normal aged person （n=50）. Comparing two groups ：（1）Blood vessel elasticity indexes： Elastic index aorta and small arteries, arterial vascular compliance, vascular stiffness and vascular wall thickness;（2）RBC oxygen capacity indexes： Determination of oxygen saturation of 50% oxygen partial pressure （P50）, enzyme-linked immunosorbent assay patient RBC 2,3-glycerol phosphate ester acid （2,3-DPG） and pyruvate kinase （PK） content;（3）Color Doppler heart function tests;（4）Static pulmonary function testing;（5） The core quality of life questionnaire （QLQ-C30） was usedto assess the quality of life for patients. Test results were statistically analyzed. Results： Large and small artery elasticity indexes of the control group were significantly higher than those in the observation group （P〈0.05）; the control group was significantly higher than that observed in vascular compliance group （P〈0.05）; and vascular stiffness in the observation group was significantly higher （P〈0.05）; arterial intima-media thickness of the observation group was larger than the control group （P〈0.05）; arterial pulse wave velocity was higher than the old observation group （P〈0.05）. Peripheral blood of patients in the observation group which was lower than the control group reached P50 （P〈0.05）; the observation group with 2,3-DPG content and PK were higher （P〈0.05）. The main indicators of heart and lung function of the observation group were better than the control group （P〈0.05）; the observation group were superior in physical, role, cognitive, emotional, and social function and the overall quality of life was significantly lower than the control gr

关 键 词：老年高血压 血管弹性 红细胞携氧能力 心肺功能 生活质量 

分 类 号：R544.1[医药卫生—心血管疾病] R592[医药卫生—内科学]