中国南方人群2型糖尿病与肺通气功能减退的关系  

Association between type 2 diabetes mellitus and lung function decline in Southern Chinese

作　　者：陈小良 程锦泉[2] 陈昌畅 陈健东 翟禹晗 余燕 林锦波[3] 季佳佳[2] CHEN Xiao - li- ang CHENG Jin - quan CHEN Chang- chang CHEN Jian - dong ZHAI Yu - hart YU Yah LIN Jin - bo Jl Jia - fla(Shenzhen Guangming District Center for Disease Control and Prevention, Shenzhen 518106, Guangdong, China.)

机构地区：[1]深圳市光明新区疾病预防控制中心慢性病防治科,广东深圳518006 [2]深圳市疾病预防控制中心分子室,广东深圳518055 [3]深圳市龙岗中心医院呼吸内科,广东深圳518116

出　　处：《广东医学》2017年第18期2840-2843,共4页Guangdong Medical Journal

基　　金：广东省自然科学基金资助项目(编号:2014A030310091);市科技计划项目(编号:JCYJ20150403095530583)

摘　　要：目的了解2型糖尿病对肺通气功能减退及慢性阻塞性肺疾病(COPD)的影响,为2型糖尿病综合干预提供依据。方法运用1∶1匹配病例对照研究方法,肺功能仪以及自制问卷现场检测和调查病例对照间肺功能与相关影响因素情况。结果共招募216对2型糖尿病病例及配对对照,用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)、用力呼气中期流速(FEF_(25-75))及呼气峰值流速(PEF)在病例组分别为(2.62±0.97)L、(2.02±0.78)L、0.77±0.10、(1.99±1.03)L/s和(5.20±2.09)L/s,在对照组分别为(2.63±0.90)L、(2.01±0.77)L、0.76±0.12、(1.90±1.07)L/s和(5.20±2.25)L/s,两组间分布差异无统计学意义(P>0.05)。调整影响因素后,2型糖尿病并未增加阻塞性肺通气功能减退(OR=0.94,95%CI:0.54~1.66)和限制性肺通气功能减退(OR=1.09,95%CI:0.57~2.10)的发生风险;另外2型糖尿病也未增加COPD的发病风险(OR=1.37,95%CI:0.73~2.57)。结论中国南方人群中2型糖尿病并未导致肺通气功能减退及COPD的发病风险增加。Objective To explore the association of type 2 diabetes mellitus with lung function decline and COPD and provide evidence for comprehensive intervention of type 2 diabetes. Methods 1 ： I matched case control study was applied to enroll the subjects, as the lung function and risk factors were investigated by the spirometer and self - made questionnaire in cases and controls. Results 216 pairs of cases and controls were recruited in this study. The means of FVC, FEV1, FEVI/FVC, FEF25 - 75 and PEF were to be （2. 62 ±0. 97） L, （2. 02 ±0. 78） L, （0. 77 ± 0. 10）, （ 1.99 ± 1.03）L/S and （5.20 ±2.09）L/S for cases as the means of them being （2.63 ±0.90）L, （2.01 ±0.77）L, （0.76 ± 0. 1 2）, （ 1.90 ±1.07） L/S and （5. 20 ± 2.25 ） L/S for controls, without statistical significance of the difference （ all P 〉 0. 05）. According to lung function classification of Wheaton AG, et al, type 2 diabetes mellitus did not increase the risks of obstructive lung function decline （ OR =0. 94, 95% CI： 0. 54 - 1.66） and restricted lung function decline （ OR = 1.09, 95%CI： O. 57 -2. 10）, and the similar result was observed in COPD （OR = 1.37, 95% CI： 0. 73 -2. 57） after adjusted the risk factors. Conclusion Type 2 diabetes mellitus does not increase the risk of pulmonary function decline and COPD in Southern Chinese.

关 键 词：2型糖尿病 肺通气功能减退 关联研究 COPD 

分 类 号：R473.6[医药卫生—护理学]