叶酸合成新方法研究  

Study on a new synthetic method of folic acid

作　　者：吕学松[1] 辛纪衡 刘晓莲[1] 徐亚威[1] 刘培臻[1] 张晓阳 刘毅[1] 

机构地区：[1]河北冀衡(集团)药业有限公司,河北衡水053000 [2]衡水市第二中学,河北衡水053000

出　　处：《煤炭与化工》2017年第5期69-71,共3页Coal and Chemical Industry

摘　　要：设计了一种合成叶酸的新方法,即以4-【[(2-氨基-3,4-二氢-4-氧代-6-蝶啶基)甲基]氨基】苯甲酰肼为原料制备叶酸,并对反应温度、溶剂等条件进行筛选,以67%收率得到叶酸,新方法收率高、不产生废水,降低了对环境的污染。A new synthetic method of folie acid was designed, which started with 4-[ [（2-amino-4-oxo-3,4-dihydropteridin -6-yl）methyl]amino]benzohydrazide.The reaction effect faetors,sueh as temperature and solvent,were studied.In the optimum condition,the yield reached 67%.The new method avoids to product waste water and reduces the pollution to the environment.

关 键 词：叶酸 叠氮化 4-【[(2-氨基-3 4-二氢-4-氧代-6-蝶啶基)甲基]氨基】苯甲酰肼合成 

分 类 号：TQ466.2[化学工程—制药化工]