Sirt1在心血管衰老中的作用机制研究进展  

Study advances in the mechanism of Sirt1 in cardiovascular aging

作　　者：宋亚男 王佼 袁丁[2] 张长城[1] 王婷[1] 周志勇[1] SONG Yan-nan WANG Jiao YUAN Ding ZHANG Chang-cheng WANG Ting ZHOU Zhi-yong(Department of Pharmacology, Three Gorges University, Hubei Yiehang 443002, China Renhe Hospital, Three Gorges University, Hubei Yiehang 443001, China)

机构地区：[1]三峡大学中药药理学实验室,湖北宜昌443002 [2]三峡大学仁和医院,湖北宜昌443001

出　　处：《中国医院药学杂志》2017年第17期1767-1770,共4页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金(81273895)

摘　　要：Sirt1是依赖于烟酰胺腺嘌呤二核苷酸(NAD+)的一类高度保守的去乙酰化酶,可将多种组蛋白和非组蛋白去乙酰化参与胰岛素分泌、血管生成、神经保护及细胞衰老等生理过程。Sirt1与心血管疾病、神经退行性疾病等衰老相关疾病的发病机理密切关系。在心血管系统中,大量研究证实,Sirt1可延缓内皮细胞衰老,改善内皮细胞功能,维持血管内稳定,从而对动脉粥样硬化、缺血再灌注损伤、心血管衰老具有重要调节作用。目前,Sirt1作为一个长寿因子受到普遍关注。本文主要从氧化应激、炎症、自噬三个方面阐述Sirt1对心血管衰老的作用机制,为寻求和研发延缓心血管衰老药物提供实验依据。Sirt1is a highly conserved NAD＋dependent protein,which can deacetylate many histone and non-histone proteins to involve in insulin secretion,angiogenesis,nerve protection,cell senescence and other physiological functions.Sirt1 has great influence on the pathogenesis of cardiovascular diseases,neurodegenerative diseases and other aging related diseases.In the cardiovascular system,a large number of studies confirm that Sirt1 can delay the aging of endothelial cells,improve endothelial functions,maintain the stability of blood vessels,thus play an important regulative role in atherosclerosis,ischemia reperfusion injury,and cardiovascular aging.At present,Sirt1 as a longevity factor has aroused widespread attentions.This article mainly illustrates the mechanism that Sirt1 acts on cardiovascular aging from three aspects：oxidative stress,inflammation and autophagy,to provide experimental evidence for research and development of drugs used for delaying the cardiovascular aging.

关 键 词：心血管疾病 氧化应激 炎症 自噬 SIRT1 

分 类 号：R966[医药卫生—药理学]