血小板反应蛋白-1在系统性红斑狼疮中的临床意义  

The clinical significance of thrombospondin-1 in systemic lupus erythematosus

作　　者：张濛[1] 孟洋[2] 甘雨舟 赵晓珍 王燕[2] 孙晓麟[3] 张学武[3] Zhang Meng Meng Yang Gan Yuzhou Zhao Xiaozhen Wang Yan Sun Xiaolin Zhang Xuewu(Department of Nephropathy Rheumatology, Nanyang Central Hospital, Affiliated to Zhengzhou University, Henan 473009, Chin)

机构地区：[1]郑州大学附属南阳市中心医院肾病风湿免疫科,473009 [2]郑州大学第五附属医院风湿免疫科 [3]北京大学人民医院风湿免疫科

出　　处：《中华风湿病学杂志》2017年第9期601-604,共4页Chinese Journal of Rheumatology

基　　金：国家自然科学基金（81471601）;北京市自然科学基金（7152150）;河南省教育厅重点科技攻关项目（14A320053）

摘　　要：目的探讨血小板反应蛋白-1（TSP-1）在SLE的临床意义，及其可能在SLE发生发展中发挥的作用。方法SLE患者138例（女性124例，男性14例），健康对照组60名，运用ELISA法检测2组血清中TSP-1表达水平，运用Spearman相关分析，分析TSP-1蛋白表达量与SLE患者补体C3、补体C4、抗dsDNA抗体、RF和SLEDAI等指标的相关性。结果健康对照组血清中TSP-1的含量（102 348±39 827）ng/ml明显高于SLE患者组（15 276±7 183）ng/ml，TSP-1与补体C3（r=0.386，P〈0.01）和补体C4（r=0.301，P〈0.01）等实验室指标呈正相关，而与SLE患者血清中抗dsDNA抗体（r=-0.221，P=0.009）、RF（r=-0.186，P=0.029）、SLEDAI（r=-0.273，P=0.001）呈负相关。结论TSP-1可能在SLE疾病过程中发挥免疫负调节功能，抑制自身免疫炎症的发展和自身抗体的产生，可能成为SLE治疗的新手段。ObjectiveTo evaluate the clinical significance of serum thrombospondin-1 （TSP-1） in systemic lupus erythematosus （SLE）, and explore its possible involvement in SLE pathogenesis.MethodsOne hundred and thirty-eight patients diagnosed with SLE, including 124 cases of females and 14 males, as well as 60 healthy controls were recruited into this study. Enzyme-linked immunosorbent assay （ELISA） was used to determine serum TSP-1 expression level between the two groups. Spearman correlation analysis method was used to analyze the correlation between TSP-1 level of complement 3, complement 4, anti-double-stranded DNA, Rheumatoid factor and systemic lupus erythematosus disease activity index （SLEDAI）.ResultsTSP-1 level in healthy control group was much higher than that in SLE patients. TSP-1 serum levels in SLE patients was positively correlated with complement 3 （r=0.386, P〈0.01）, complement 4 （r=0.301, P〈0.01）, and negatively correlated with anti-double-stranded DNA （r=-0.221, P=0.009）, RF （r=-0.186, P=0.029） and SLEDAI （r=-0.273, P=0.001）.ConclusionTSP-1 may play an immune-regulatory role in the development of SLE by inhibiting inflammation and autoantibody production. It could become a potential therapeutic target for the treatment of SLE.

关 键 词：红斑狼疮 系统性 血小板反应蛋白-1 

分 类 号：R593.241[医药卫生—内科学]