微流光反应技术制备树脂状维生素D_3  

Preparation of Resin-like Vitamin D_3 by Micro-flow Photoreaction

作　　者：李超[1] 周前雄[1] 张宝文[1] 王雪松[1] 

机构地区：[1]中国科学院理化技术研究所光化学转换与功能材料重点实验室,北京100190

出　　处：《影像科学与光化学》2017年第5期667-674,共8页Imaging Science and Photochemistry

摘　　要：合成维生素D_3的关键步骤是7-去氢胆固醇光照开环合成预维生素D_3,目前合成是在釜式光反应器中进行,原料转化率低,产物提纯难度大,产品生产周期长。本文利用微流光反应技术开展预维生素D_3的制备研究,与传统釜式光反应器相比,原料转化率从低于30%提高到95%,光照产物无需纯化,可直接通过热异构化反应制备树脂状维生素D_3,生产周期大为缩短。The key process in the synthesis of vitamin D3 is the photochemical conversion from 7-dehydrocholesterol to pre-vitamin D3,which is currently carried out in batch photoreactors and suffers from low conversion efficiency,recycle of unreacted 7-dehydrocholesterol,and long production period.Using micro-flow photoreactor instead of batch photoreactor,the conversion yield of 7-dehydrocholesterol may be increased from less than 30% to over 95%,allowing the photoreaction product to be directly used to prepare resin-like vitamin D3 through a thermal isomerization reaction and shortening the production period greatly.

关 键 词：维生素D3 7-去氢胆固醇 预维生素D3 微流光化学反应器 

分 类 号：TQ466.4[化学工程—制药化工]