葛根、葛花、枳椇子混合物对小鼠急性酒精中毒醒酒作用的研究  

Anti-alcoholism effects of Puerariae lobatae radix,Puerariae lobatae flowers,Hovenia dulcis thunb mixture on acute alcoholism mice

作　　者：王洁 周瑢[2] 潘晓薇[2] 陆一鸣 陶红[2] 

机构地区：[1]第二军医大学药学院生化药学教研室,上海200433 [2]广东中烟工业有限责任公司,广东广州510385

出　　处：《药学实践杂志》2017年第5期398-401,410,共5页Journal of Pharmaceutical Practice

基　　金：广东中烟工业有限责任公司科技项目"中草药解酒复方的作用及其在卷烟中的效果评价研究"(粤烟工[2013]科字第02号)

摘　　要：目的探讨中药葛根、葛花、枳椇子混合物对小鼠急性酒精中毒的醒酒效果。方法采用酒精灌胃法建立小鼠急性酒精中毒模型,观察混合物不同配比对小鼠的醒酒效果,选择最佳配比;按最佳配比将小鼠分为低剂量组和高剂量组,通过测定小鼠的耐受时间、醉酒时间、血液中的乙醇浓度和肝中乙醇脱氢酶的活性观察葛根、葛花、枳椇子混合物的醒酒效果。结果葛根、葛花、枳椇子混合物能够增加小鼠对酒精的耐受时间,同时缩短小鼠的醉酒时间,降低血液中的乙醇浓度,提高肝中乙醇脱氢酶的活性。结论葛根、葛花、枳椇子混合物对小鼠急性酒精中毒具有醒酒作用。Objective To study the anti-alcoholism effect of Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture on acute alcohol poisoning in mice.Methods A model of acute alcoholism in mice was established by intragastrical administration of alcohol.The best ratio of each component in the mixture was identified by observing the sobering effect of the mixtures on mice.The best ratio mixture was divided into low dose group and high dose group.The mice tolerance time, drunken time, the ethanol concentration in the blood and the alcohol dehydrogenase activity in liver were measured to study the anti-alcoholism effect of the mixture.Results The Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture not only increased the tolerance time and decreased the drunken time of mice, but also significantly reduced the ethanol concentration in blood and improved the activity of alcohol dehydrogenase in liver.Conclusion This study found that Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture has anti-alcoholism effect on acute alcoholism in mice.

关 键 词：葛根 葛花 枳椇子 乙醇浓度 乙醇脱氢酶 

分 类 号：R285.5[医药卫生—中药学]