miRNA在ARDS中的作用研究进展  

Advances of miRNA in acute respiratory distress syndrome

作　　者：朱端 胡晨 胡建林[1] 

机构地区：[1]第三军医大学西南医院呼吸内科,重庆400038 [2]第三军医大学大坪医院呼吸内科,重庆400042

出　　处：《国际呼吸杂志》2017年第18期1416-1420,共5页International Journal of Respiration

基　　金：国家自然科学基金面上资助项目（81670070）

摘　　要：ARDS为常见且复杂的炎症性肺疾病，发病机制错综复杂，以肺内严重炎症反应导致肺泡上皮及毛细血管内皮损伤和功能障碍为特征，并存在细胞凋亡及肺泡液体清除异常等，最终导致肺换气功能障碍，表现为严重呼吸困难及低氧血症。微小RNA（miRNA）作为一类新型的基因调控分子，在许多疾病包括ARDS的发病过程中发挥着至关重要的作用。在肺损伤和修复过程中，特定种类的miRNA表达异常，并通过影响其靶基因的表达而调控炎症通路和免疫反应。Acute respiratory distress syndrome （ARDS） is a common and complex inflammatory lung disease. The pathogenesis of ARDS is complicated. ARDS is characterized by severe inflammation in the lung leading to disruption of alveolar endothelial barrier and also involved apoptosis and alveolar fluid clearance abnormity. Together, these pathologies cause pulmonary ventilation dysfunction and severe hypoxaemia. As a new type of gene regulator, microRNA plays vital roles in many diseases, including ARDS. During the process of lung injury and repair, certain kinds of microRNA are abnormally expressed and can modulate inflammation pathways as well as immune response by affecting expressions of target genes.

关 键 词：微小RNA 急性呼吸窘迫综合征 炎症 免疫反应 

分 类 号：R563.8[医药卫生—呼吸系统]