应用自-异体混编肌腱重建兔前交叉韧带的生物力学分析  

Biomechanical analysis of application of auto/allo-graft reconstruction of the anterior cruciate ligament in rabbits

作　　者：谢迎[1] 何俊山[2] 王亚东[2] 吴继云[2] 邓亚开 陈伟南[1,2] 

机构地区：[1]安徽医科大学无锡临床学院骨科,无锡214044 [2]中国人民解放军第101医院骨科,无锡214044

出　　处：《安徽医科大学学报》2017年第10期1437-1440,共4页Acta Universitatis Medicinalis Anhui

基　　金：南京军区重大研究专项项目(编号:12MA011)

摘　　要：目的比较应用兔的自-异体混编肌腱与异体肌腱重建前交叉韧带(ACL)的生物力学特性方面的差异。方法兔40只,随机分成混编组及异体组,每组20只,分4个时间节点(术后3、8、12、24周),每个时间节点样本量为5只。均行右膝关节ACL重建。混编组采用自体肌腱与异体肌腱混合编织后重建ACL,异体组则完全采用异体肌腱编织后重建ACL。分别于术后3、8、12、24周处死每组的5只兔子,取右膝关节制成标本,行单轴拉力实验并对实验数据进行统计分析。结果术后3、8、12、24周,标本拉力测试显示,混编组的极限负荷、刚度均高于异体组,混编组拉伸长度均低于异体组,两组比较差异有统计学意义(P<0.05)。术后3、8周标本毁损模式两组均以移植物自骨隧道拔出为主,术后12、24周两组均多为移植物实质部断裂。4个时间节点毁损模式Fisher确切检验均差异无统计学意义。结论重建ACL,自-异体混编肌腱的生物力学特性优于异体肌腱。Objective To compare the differences of biomechanical properties between using auto/allo-graft and al- lo-graft in anterior cruciate ligament（ACL） reconstruction in rabbits. Methods 40 rabbits were randomly divided into auto/allo-graft group and allo-graft group（n=20）, 4 time node （3,8,12,24 weeks）, the number of samples at each time point was 5. The right knee joint underwent ACL reconstruction. Auto-graft and allo-graft mixed woven was used in auto/allo-graft groupbut allo-graft group completly used allograft tendon. Five rabbits in each group were killed at 3, 8, 12 and 24 weeks after operation. The specimens were taken from the right knee joint, and the uniaxial tensile experiment was carried out and the experimental data were analyzed statistically. Results After 3, 8,12,24 weeks, the tensile test of specimens showed that the limited load and stiffness of auto/allo-graft group were higher than the allo-graft group, but the stretched length of auto/allo-graft group were lower than the allo-graft group , the difference between the two groups were statistically significant （ P 〈 0. 05 ）. 3, 8 weeks after operation, the damaged mode of two groups were mostly represent the graft pull out the tunnel, but 12,24 weeks after opera- tion in two groups were more substantial graft rupture. There was no significant difference in Fisher exact test at 4 time points. Conclusion The reconstruction of ACL,the auto/allo-graft is better than the allo-graft in biomechani- ca1 properties.

关 键 词：前交叉韧带 自-异体混编肌腱 异体编织肌腱 生物力学 

分 类 号：R686.5[医药卫生—骨科学]