口服锌制剂对轮状病毒感染所致肠炎患儿病情复发的影响  

Effect of oral zinc preparation on the recurrence of children with enteritis caused by rotavirus infections

作　　者：王伟荣[1] 李玲[1] 唐碧波[1] 李如伟 王丽珍 

机构地区：[1]儋州市第一人民医院儿科,海南儋州571700

出　　处：《中华医院感染学杂志》2017年第17期4020-4023,共4页Chinese Journal of Nosocomiology

摘　　要：目的探究口服锌制剂对轮状病毒感染所致肠炎患儿的治疗效果,以及治疗后3、6个月内患儿病情复发情况。方法选取2014年2月-2016年6月于医院接受治疗的162例患儿为研究对象,按照随机数表法平均分成观察组与对照组,每组各81例;对照组接受常规治疗方案,观察组在常规治疗基础上添加口服锌制剂治疗,比较两组患儿治疗效果及治疗前后身体功能性损伤情况,统计并分析两组患儿治疗后肠炎复发例数以及安全性评分。结果观察组患儿接受口服锌制剂治疗后中重度脱水、肝脏功能以及呼吸道损伤症状均有所好转,患儿患病例数明显减少,而对照组患儿治疗后效果不显著,减少的例数不明显;治疗后两组患儿治疗效果差异较大,其中观察组患儿显效率明显高于对照组,两组治疗效果比较,差异有统计学意义(χ~2=6.438,P<0.05);病情复发情况显示,观察组及对照组患儿的腹泻呕吐现象随着时间的延长逐渐减少,但对照组患儿在治疗后1、3、6个月三个时间段内腹泻以及呕吐的复发例数均比观察组多,观察组在治疗后6个月的电话随访发现呕吐复发例数仅有2例(2.4%),而腹泻复发例数仅有1例(1.2%),常规治疗添加口服锌制剂治疗轮状病毒较常规治疗有效,治疗后复发率低,差异有统计学意义(χ~2=6.217,P<0.05);安全性方面,观察组安全评分(93.13±4.99)分较对照组(75.49±8.41)分高。结论口服锌制剂对轮状病毒感染所致肠炎患儿的治疗效果显著,能有效降低患儿治疗后病情复发率,且能有效减轻病毒感染致肠炎患儿复发时的腹泻、呕吐症状。OBJECTIVE To explore the therapeutic effect of oral zinc preparation on children with enteritis caused by rotavirus infections and the recurrence of the disease in 3 months and 6 months after treatment.METHODS A total of 162 children with rotavirus infections from Feb.2014 to Jun.2016 in our hospital were selected as the research subjects,and were divided into observation group and control group according to randomly table method,with 81 cases in each group.The control group was treated with conventional therapy,while the observation group was given additional oral zinc preparation on basis of the conventional therapy.The treatment effect was compared between the two groups of children,the incidence of functional injury was statistically analyzed before and after the treatment,the number of cases of recurrent rotavirus enteritis was statistically analyzed after the treatment,and the safety score was evaluated.RESULTS The moderate and severe dehydration,liver function and respiratory tract injury symptoms were improved in observation group after oral zinc preparation treatment,and the sick children were significantly reduced,while in control group after treatment,the effect was not significant,and the reducing cases was not significant.After treatment,the two groups of children had different treatment effects,in which the effective rate of observation group was significantly higher than that of control group（χ^2=6.438,P〈0.05）.The recurrence of the disease showed that the diarrhea and vomiting in observation group and control group were gradually decreased with the prolonging of time,but the number of recurrent diarrhea and vomiting in control group was more than that in observation group at the three time points of 1,3 and 6 months after treatment.There were 2 cases（2.4%）of vomiting recurrence and 1 case（1.2%）of diarrheain recurrence in observation group within 6 months of telephone follow-up after treatment.Routine treatment with zinc oral preparation was more effective than conventional therapy in

关 键 词：口服锌制剂 轮状病毒感染致肠炎 病情复发 

分 类 号：R373.2[医药卫生—病原生物学]