督促干预对艾滋病患者肺结核感染的治疗效果分析  

Therapeutic effects of supervision and intervention on HIV/AIDS and TB infections

作　　者：卡丽毕努尔.力提甫 林栋羚[2] 宋江美[2] 何丽[2] 郭静[2] 

机构地区：[1]新疆医科大学第一附属医院护理部,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院感染性疾病中心,新疆乌鲁木齐830054

出　　处：《中华医院感染学杂志》2017年第17期4041-4044,共4页Chinese Journal of Nosocomiology

基　　金：新疆医科大学第一附属医院科研基金项目(2015GL20)

摘　　要：目的探究督促干预对艾滋病合并肺结核双重感染患者抗结核和抗病毒治疗的效果。方法选取2014年5月-2016年7月于医院治疗的82例艾滋病及肺结核双重感染患者(AIDS/TB)为研究对象,将82例患者根据随机数表法分为对照组41例和观察组41例;对两组患者均进行高效抗逆转录病毒治疗(HAART)的同时,根据病情使用抗结核组合药物治疗,观察组在对照组患者治疗基础上辅以督促干预;在治疗后使用诺丁汉健康调查问卷对两组患者生活质量进行评分,比较两组患者治疗后的病情改善情况及治疗前后肺功能指标水平。结果对照组患者诺丁汉健康调查问卷结果:精力评分7.6±2.1、疼痛评分2.7±0.8、情感评分4.5±0.8、睡眠评分9.1±3.1、社会活动2.6±0.8和身体活动3.1±0.9,总分31.9±1.8,观察组患者结果:精力评分5.3±1.7、疼痛评分2.5±0.9、情感评分3.2±0.7、睡眠评分7.4±2.8、社会活动1.3±1.0和身体活动1.4±0.9,总分21.6±0.9,两组患者评分除疼痛评分外差异均有统计学意义(P<0.05);对照组患者治疗后病情改善情况:明显改善12例,改善24例,无效5例,总有效率87.8%,观察组明显改善17例,改善22例,无效2例,总有效率95.1%,对照组和观察组患者病情改善情况比较差异有统计学意义(P<0.05);治疗前对照组患者与观察组患者肺功能指标比较差异无统计学意义,对照组患者治疗后FVC、FEV1/FVC和CD4+T细胞含量分别为76.9±4.3、75.4±4.7和258.4±141.7/ul,观察组患者治疗后分别为83.1±4.5、81.7±4.4和286.1±143.8/ul,两组患者治疗后数据比较,差异有统计学意义(P<0.05)。结论督促干预对艾滋病合并肺结核双重感染患者生活质量的提高、病情改善和肺功能恢复有着良好效果。OBJECTIVE To investigate the effects of supervision and intervention on anti-tuberculosis and antiviral treatment of HIV/AIDS patients with dual infections of tuberculosis and to find a better way to treat infected patients.METHODS A total of 82 cases of AIDS and pulmonary tuberculosis（AIDS/TB）from May 2014 to Jul.2016 in our hospital were selected as the research subjects,and were randomly divided into control group of 41 cases and observation group of 41 cases.The two groups of patients were treated with highly active antiretroviral therapy（HAART）,and the combination of anti tuberculosis drug treatment was used according to the disease conditions at the same time.Patients in observation group were treated with supervision and intervention on the basis of the treatment of control group.Two groups were measured and compared with the quality of life of Nottingham health questionnaire before and after the treatment,the improvement of the patients′ conditions and the levels of pulmonary function indexes before and after treatment were compared between the two groups.RESULTS The scores of the Nottingham Health Questionnaire in control group were： safety score of 7.6±2.1,pain score of 2.7±0.8,emotional score of 4.5±0.8,sleep score of 9.1±3.1,social activity of 2.6±0.8 and physical activity of 3.1±0.9,and the total score was 31.9±1.8;in observation group were： safety score of 5.3±1.7,pain score of 2.5±0.9,emotion score of 3.2±0.7,sleep score of 7.4±2.8,social activity of 1.3±1.0 and physical activity of 1.4±0.9,and the total score was 21.6±0.9,the differences were significant except the pain score（P〈0.05）the two groups（P〈0.05）.In control group,the patients were significantly improved in 12 cases,improved in 24 cases,ineffective in 5 cases,and the overall limited rate was 87.8%.In observation group,the patients were significantly improved in 17 cases,improved in 22 cases,ineffective in 2 cases,and the overall limited rate was 95.1%.The improvement of the patients′ conditions bet

关 键 词：督促干预 肺结核 艾滋病 治疗效果 

分 类 号：R521[医药卫生—内科学]