2型糖尿病周围神经病变的影响因素分析  

Analysis of influential factors of peripheral neuropathy in type 2 diabetic mellitus patients

作　　者：丁丽萍[1] 卓林[1] 徐春[1] 丁美[1] 李雪梅[1] DING Li-ping ZHUO Lin XU Chune et al(Department of Endocrinology, Hulun Buir People＇s Hospital （Inner Mongolia University for Nationalities Clinical Medical College）, Hulun Buir 021008, China)

机构地区：[1]呼伦贝尔市人民医院内分泌科(内蒙古民族大学呼伦贝尔临床医学院),021008

出　　处：《中国实用医药》2017年第25期28-30,共3页China Practical Medicine

摘　　要：目的探讨研究2型糖尿病周围神经病变的影响因素。方法选取126例2型糖尿病患者,其中82例2型糖尿病合并周围神经病变患者作为观察组,44例2型糖尿病非合并周围神经病变患者作为对照组,对两组患者各项临床指标进行检查和比较,分析2型糖尿病周围神经病变的影响因素。结果两组患者的年龄、体质量指数、收缩压、舒张压、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(Ins)指标比较差异无统计学意义(P>0.05)。观察组患者病程显著长于对照组,空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、尿微量白蛋白肌酐比值(ACR)、C反应蛋白(CRP)和同型半胱氨酸(Hcy)水平显著高于对照组,2 h胰岛素(2 h Ins)显著低于对照组,差异均具有统计学意义(t=7.78、3.65、7.44、5.13、9.38、12.59、20.91、13.88,P<0.05)。结论 2型糖尿病合并周围神经病变的主要影响因素为糖尿病病程、糖化血红蛋白、尿微量白蛋白肌酐比值、C反应蛋白、同型半胱氨酸等,临床上需要加强预防和控制。Objective To investigate the influential factors of peripheral neuropathy in type 2 diabetic mellitus patients.Methods Among 126 type 2 diabetic mellitus patients,there were 82 patients with type 2 diabetic mellitus and peripheral neuropathy as observation group,and 44 patients with type 2 diabetic mellitus and non-peripheral neuropathy as control group.The clinical indexes of two groups of patients were examined and compared,and the influencing factors of peripheral neuropathy in type 2 diabetes mellitus were analyzed.Results Both groups had no statistically significant difference in age,body mass index,systolic blood pressure,diastolic blood pressure,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,and fasting insulin（Ins）（P〉0.05）.The observation group had obviously longer course of disease than the control group,and obviously higher fasting blood glucose（FBG）,postprandial 2 h blood glucose（2 h PG）,glycosylated hemoglobin（Hb A1c）,urinary albumin creatinine ratio（ACR）,C reactive protein（CRP） and homocysteine（Hcy） than the control group,and obviously lower 2 h insulin（2 h Ins） than the control group.Their difference was statistically significant（t=7.78,3.65,7.44,5.13,9.38,12.59,20.91,13.88,P〈0.05）.Conclusion The main influencing factors of type 2 diabetes mellitus and peripheral neuropathy are diabetes mellitus course,glycosylated hemoglobin,urinary albumin creatinine ratio,C-reactive protein and homocysteine,and it is necessary to strengthen clinical prevention and control.

关 键 词：2型糖尿病 周围神经病变 影响因素 

分 类 号：R587.2[医药卫生—内分泌]