医学营养和运动联合干预对妊娠期高血压患者胎盘缺血缺氧损伤、血清中血管新生因子的影响  

Effect of medical nutrition combined with exercise intervention on the placental ischemic hypoxic injury and serum angiogenesis factors in patients with gestational hypertension

作　　者：胡良慧[1] 谢萍[1] 陈德慧[1] 

机构地区：[1]四川省自贡市第三人民医院妇产科,四川自贡643020

出　　处：《海南医学院学报》2017年第15期2123-2126,共4页Journal of Hainan Medical University

基　　金：四川省科技局课题项目(100895)

摘　　要：目的:探讨医学营养和运动联合干预对妊娠期高血压患者胎盘缺血缺氧损伤、血清中血管新生因子的影响。方法:收集在本院进行产检及分娩的妊娠期高血压患者90例,随机分为对照组、观察组各45例。对照组接受常规治疗,观察组接受常规治疗+营养联合运动干预,对比两组胎盘组织中缺血缺氧损伤指标表达量、分娩前血清中血管新生因子含量的差异。结果:干预后,观察组胎盘碾磨液中缺血缺氧损伤性指标NO的含量高于对照组患者,ET-1、HIF-1α、Bax、Caspase-3、MDA的含量低于对照组;血清中血管新生因子TGFβ1、HGF、bFGF、VEGF、Ang-2的含量均显著高于对照组患者,sFlt-1的含量低于对照组患者(P<0.05)。结论:医学营养和运动联合干预可有效减少妊娠期高血压患者的胎盘缺血缺氧损伤,减少血管新生。Objective： To discuss the effect of medical nutrition combined with exercise intervention on the placental ischemic hypoxic injury and serum angiogenesis factors in patients with gestational hypertension. Methods： A total of 90 patients with gestational hypertension who received antenatal care and gave birth in our hospital were collected and divided into control group and observation group according to random number table, 45 cases in each group. Control group of patients received routine therapy, observation group of patients received routine therapy ＋ nutrition combined with exercise intervention, and the differences between two groups of patients of ischemic hypoxic injury index expression in placenta tissue and serum angiogenesis factor levels before delivery were compared. Results： After intervention, ischemie hypoxic injury index NO level in placental grinding fluid of observation group was higher than that of control group, while ET-1, HIF-1α, Bax, Caspase-3 and MDA lev- els of observation group were lower than those of control group; serum angiogenesis factors TGF/31, HGF, bFGF, VEGF and Ang-2 levels of observation group were significantly higher than those of control group, while sFlt-1 level of observation group was lower than that of control group （P〈0.05）. Conclusion： The combination of medical nutrition and exercise can effectively reduce the placental ischemic hypoxic injury and the angiogenesis in patients with gestational hypertension.

关 键 词：妊娠期高血压 营养干预 运动干预 胎盘缺血缺氧 血管新生因子 

分 类 号：R714.246[医药卫生—妇产科学]