益气活血通脉汤治疗2型糖尿病周围神经病变的临床研究  

Clinical Observation of Yiqi Huoxue Tongmai decoction in the Treatment of Type 2 Diabetic Peripheral Neuropathy

作　　者：邓翠 李京[2,3] 汤秀珍 DENG Cui LI Jing TANG Xiu-zhen(Benxi Chinese Medicine Hospital, Benxi 117000, China General Hospital of Shenyang Military Region, Shenyang 110086, China Traditional Chinese Medicine Hospital of Kuandian Manchu Autonomous County, Dandong 118200, China)

机构地区：[1]本溪市中医院,辽宁本溪117000 [2]沈阳军区总医院,辽宁沈阳110086 [3]宽甸满族自治县中医院,辽宁丹东118200

出　　处：《中医药信息》2017年第5期65-69,共5页Information on Traditional Chinese Medicine

基　　金：辽宁省科技厅科研基金(No.2012225018);辽宁省科学技术基金(No.20092038)

摘　　要：目的:探讨益气活血通脉汤治疗2型糖尿病周围神经病变的临床疗效。方法:选取符合纳入标准的2型糖尿病周围神经病变患者92例,按随机数字表法分为对照组和研究组,对照组46例予以甲钴胺治疗,研究组46例在对照组基础上予以益气活血通脉汤治疗,检测治疗前后两组患者神经传导速度、血液流变学指标、氧化应激水平,同时比较临床疗效。结果:对照组治疗有效率(71.74%)低于研究组(89.13%),具有统计学意义(P<0.05);与对照组比较,治疗后研究组正中神经MNCV、SNCV及腓总神经MNCV、SNCV改善情况优于对照组,治疗后血浆黏度、高切全血黏度、低切全血黏度及红细胞聚集指数水平低于对照组,治疗后血清SOD、GSH-Px、T-AOC水平升高,血清MDA水平降低,与对照组比较具有统计学意义(P<0.05)。结论:益气活血通脉汤能提高2型糖尿病周围神经病变患者神经传导速度,改善血液流变学指标,减轻氧化应激反应,临床疗效显著。Objective：To investigate the clinical curative effect of Yiqi Huoxue Tongmai decoction in the treatment of type 2 diabetic peripheral neuropathy.Methods：92 cases were randomly divided into the control group and the observation group.46 patients were treated with Mecobalamine in the control group,and 46 patients in the observation group were also given Yiqi Huoxue Tongmai decoction besides Mecobalamine.Nerve conduction velocity,indexes of hemorheology and oxidative stress,and the clinical efficacy were compared between the two groups before and after treatment.Results：The effective rate in the control group was 71.74%,which was lower than 89.13% in the observation group,which had a statistical significance （P〈0.05）;For the observation group after treatment,the levels of MNCV and SNCV from the median nerves and peroneal nerves were higher,levels of plasma viscosity,high-shear phase blood viscosity,low-shear phase blood viscosity and erythrocyte assembling index（EAI） were reduced,the levels of SOD、GSH-Px、T-AOC were higher,and the level of MDA was lower compared to that of the control group,in which there were statistical significances （P〈0.05）.Conclusion：Yiqi Huoxue Tongmai decoction can improve nerve conduction velocity and hemorheology index,and it can reduce the oxidative stress reaction in patients with type 2 diabetic peripheral neuropathy with a significant clinical efficacy.

关 键 词：益气活血通脉汤 2型糖尿病周围神经病变 临床疗效 神经传导速度 血液流变学 氧化应激 

分 类 号：R259[医药卫生—中西医结合]