慢性阻塞性肺病急性发作期患者皮质醇节律紊乱的相关研究  

Research on the Cortisol Rhythm Disorder in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：高英翠 闵晓霞[1] 程韵如 GAO Ying-cui MIN Xiao-xia CHENG Yun-ru(The 6^th People＇ s Hospital of Chengdu, Chengdu 610051 , China)

机构地区：[1]成都市第六人民医院核医学科,四川成都610051 [2]成都市第六人民医院呼吸科,四川成都610051

出　　处：《标记免疫分析与临床》2017年第9期1022-1024,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨慢性阻塞性肺炎(chronic obstructive pulmonary disease,COPD)患者急性发作期血浆皮质醇含量及节律变化。方法选取51例COPD急性发作期患者及50例COPD稳定期患者,并随机选择正常对照组51例,分别于入院后第二日早晨8∶00、下午16∶00与夜间00∶00不同时段采集静脉血,采用化学发光法检测皮质醇的水平,并对其结果进行分析。结果COPD患者急性发作期8AM血浆皮质醇含量明显低于COPD稳定期患者及正常对照组,差异具有统计学意义(P<0.05);三组结果在4PM、0AM比较,差异无统计学意义(P>0.05);根据皮质醇节律紊乱诊断标准,51例患者中有48例存在节律紊乱。结论慢性阻塞性肺炎急性加重期(AECOPD)患者肾上腺皮质功能会出现障碍,并且皮质醇分泌节律发生紊乱。Objective To investigate the changes of plasma cortisol and rhythm in patients of acute exacerbation of chronic obstructive pulmonary disease （COPD）.Methods 51 patients with acute exacerbation of COPD were selected as experimental group （n=51）, and 50 stable patients with COPD were selected as stable group（n=50）,while 51 normal people were randomly selected as control group （n=51）.Venous blood was collected on the second day at 8：00AM, 4：00PM and 0：00AM,respectively.Detection and analysis the cortisol levels were conducted by chemiluminescence.Results At 8AM,plasma cortisol levels in patients with acute exacerbation of COPD were significantly lower than those in the stable group and the control group, the difference was statistically significant（P〈0.05）;When compared the results of three groups at 4 PM, 0 AM, there is no statistical significance（P〉0.05）.According to the diagnostic criteria of the cortisol rhythm disorder, 48cases were rhythm disorderedin 51 cases.Conclusion In patients with AECOPD, there is an obstacle to the adrenal cortex and the disorder of cortisol secretion.

关 键 词：COPD 皮质醇节律 紊乱 

分 类 号：R563.9[医药卫生—呼吸系统]