血清载脂蛋白CⅢ水平与老年急性冠脉综合征病人冠状动脉病变程度的相关性研究  

Correlation between serum level of ApoCⅢ and severity of coronary artery stenosis in elderly patients with acute coronary syndrome

作　　者：李亚伟[1] 韩静[2] 江平[1] 王立君[1] 杜超[1] 张军惠[1] 

机构地区：[1]石家庄市第三医院心内一科,河北省石家庄市050000 [2]河北医科大学第二医院体检部,河北省石家庄市050000

出　　处：《实用老年医学》2017年第9期862-865,共4页Practical Geriatrics

摘　　要：目的探讨老年急性冠脉综合征(ACS)病人血清中载脂蛋白CⅢ(Apo CⅢ)水平与血脂及冠脉病变程度的相关性。方法选取110例ACS病人作为研究对象(ACS组),依据病变程度将其分为ACS单支病变组和ACS多支病变组,每组各55例;同时另选取健康体检者100例作为对照组,比较ACS组与对照组一般临床资料,以及对照组、ACS单支病变组和ACS多支病变组血脂、脂蛋白α(Lpα)、载脂蛋白AⅠ(Apo A-Ⅰ)及Gensini评分,并分析Apo CⅢ水平与上述指标的相关性。结果 ACS组的男性与吸烟者比例均显著高于对照组,差异有统计学意义(P<0.05);ACS单支病变组和ACS多支病变组的低密度脂蛋白胆固醇(LDL-C)、Lpα、ApoCⅢ水平及Gensini评分均显著高于对照组(P<0.05),且ACS多支病变组上述指标均显著高于ACS单支病变组(P<0.05);3组Apo A-Ⅰ水平比较,对照组>ACS单支病变组>ACS多支病变组,差异有统计学意义(P<0.05);ACS多支病变组高密度脂蛋白胆固醇(HDL-C)水平低于对照组,差异有统计学意义(P<0.05)。相关性分析结果表明,Apo CⅢ与总胆固醇(TC)、甘油三脂(TG)、LDL-C、Lpα、冠状动脉病变支数及Gensini评分呈正相关(P<0.05),与HDL-C及Apo A-Ⅰ水平呈负相关(P<0.05)。结论老年ACS病人血清Apo CⅢ升高,且与冠状动脉病变程度有关,ApoCⅢ可能参与了ACS的发生和发展。Objective To investigate the change of serum level of Apo CⅢ in elderly patients with acute coronary syndrome（ ACS）,and to explore the correlation with the levels of serum lipids and severity of coronary artery stenosis. Methods 110 patients with ACS were selected as the subjects（ ACS group）,and according to the extent of the lesions they were divided into single vessel lesion group（ n =55） and multiple vessel lesion group（ n = 55）; At the same time,100 healthy subjects were selected as control group. The general clinical data were compared between the ACS group and the control group.And the levels of blood lipid,lipoprotein alpha（ Lpα）,apolipoprotein and Gensini score were compared among the control group,single vessel lesion group and ACS multiple vessel lesion group,and the correlation between Apo C Ⅲ and the above indexes was analyzed. Results Proportion of male and smoking in ACS group were significantly higher than those in the control group（ P〈0. 05）; The levels of low density lipoprotoin cholesterol（ LDL-C）,Lpα,Apo C Ⅲ and Gensini scores of single vessel lesion group and multiple vessel lesion group were significantly higher than those of the control group,and all above parameters in multiple vessel lesion group were significantly higher than those of single vessel lesion group（ P〈0. 05）; The level of Apo A-Ⅰ was lower in single vessel lesion group and multiple vessel lesion group compared to the control group,especially lower in multiple vessel lesion group（ P〈0. 05）; And the level of high density liporotein cholesterol（ HDL-C） in multiple vessel lesion group was significantly lower than that in control group（ P〈0. 05）; Correlation analysis showed that,the concentration of Apo CⅢ was positively correlated with the levels of total cholesterol（ TC）,TG,LDL-C,Lpα,the severity of coronary artery stenosis and Gensini score（ P 0. 05）,and negatively correlated with the levels of HDL-C and Apo A-Ⅰ（ P〈0. 05）. Conclusions The level of

关 键 词：急性冠脉综合征 载脂蛋白CⅢ 冠状动脉病变程度 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]